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Direct interaction between centralspindlin and PRC1 reinforces mechanical
resilience of the central spindle
#MMPMID26088160
Lee KY
; Esmaeili B
; Zealley B
; Mishima M
Nat Commun
2015[Jun]; 6
(?): 7290
PMID26088160
show ga
During animal cell division, the central spindle, an anti-parallel microtubule
bundle structure formed between segregating chromosomes during anaphase,
cooperates with astral microtubules to position the cleavage furrow. Because the
central spindle is the only structure linking the two halves of the mitotic
spindle, it is under mechanical tension from dynein-generated cortical pulling
forces, which determine spindle positioning and drive chromosome segregation
through spindle elongation. The central spindle should be flexible enough for
efficient chromosome segregation while maintaining its structural integrity for
reliable cytokinesis. How the cell balances these potentially conflicting
requirements is poorly understood. Here, we demonstrate that the central spindle
in C. elegans embryos has a resilient mechanism for recovery from perturbations
by excess tension derived from cortical pulling forces. This mechanism involves
the direct interaction of two different types of conserved microtubule bundlers
that are crucial for central spindle formation, PRC1 and centralspindlin.
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