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10.1038/ncomms8321 http://scihub22266oqcxt.onion/10.1038/ncomms8321 C4557301!4557301!26084661     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26084661|t=2015. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin |pdf=|usr=}}{{26084661}} gab.com Text Exosome-delivered microRNAs modulate the inflammatory response to endotoxin JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26084661 #FOAvip MicroRNAs regulate gene expression posttranscriptionally and function within the cells in which they are transcribed. However, recent evidence suggests that microRNAs can be transferred between cells and mediate target gene repression. We find that endogenous miR-155 and miR-146a, two critical microRNAs that regulate inflammation, are released from dendritic cells within exosomes and are subsequently taken up by recipient dendritic cells. Following uptake, exogenous microRNAs mediate target gene repression and can reprogramme the cellular response to endotoxin, where exosome-delivered miR-155 enhances while miR-146a reduces inflammatory gene expression. We also find that miR-155 and miR-146a are present in exosomes and pass between immune cells in vivo, as well as demonstrate that exosomal miR-146a inhibits while miR-155 promotes endotoxin-induced inflammation in mice. Together, our findings provide strong evidence that endogenous microRNAs undergo a functional transfer between immune cells and constitute a mechanism of regulating the inflammatory response. Twit Text FOAVip Exosome-delivered microRNAs modulate the inflammatory response to endotoxin ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26084661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26084661 #FOAvip English Wikipedia <ref>{{Cite pmid|26084661}}</ref> Exosome-delivered microRNAs modulate the inflammatory response to endotoxin #MMPMID26084661 Alexander M; Hu R; Runtsch MC; Kagele DA; Mosbruger TL; Tolmachova T; Seabra MC; Round JL; Ward DM; O'Connell RM Nat Commun 2015[]; 6 (ä): ä PMID26084661show ga MicroRNAs regulate gene expression posttranscriptionally and function within the cells in which they are transcribed. However, recent evidence suggests that microRNAs can be transferred between cells and mediate target gene repression. We find that endogenous miR-155 and miR-146a, two critical microRNAs that regulate inflammation, are released from dendritic cells within exosomes and are subsequently taken up by recipient dendritic cells. Following uptake, exogenous microRNAs mediate target gene repression and can reprogramme the cellular response to endotoxin, where exosome-delivered miR-155 enhances while miR-146a reduces inflammatory gene expression. We also find that miR-155 and miR-146a are present in exosomes and pass between immune cells in vivo, as well as demonstrate that exosomal miR-146a inhibits while miR-155 promotes endotoxin-induced inflammation in mice. Together, our findings provide strong evidence that endogenous microRNAs undergo a functional transfer between immune cells and constitute a mechanism of regulating the inflammatory response. äExosome-delivered microRNAs modulate the inflammatory response to endo(epmc).pdf DeepDyve Pubget Overpricing