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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Commun
2015 ; 6
(ä): 7981
Nephropedia Template TP
gab.com Text
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English Wikipedia
The SnRK2-APC/C(TE) regulatory module mediates the antagonistic action of
gibberellic acid and abscisic acid pathways
#MMPMID26272249
Lin Q
; Wu F
; Sheng P
; Zhang Z
; Zhang X
; Guo X
; Wang J
; Cheng Z
; Wang J
; Wang H
; Wan J
Nat Commun
2015[Aug]; 6
(ä): 7981
PMID26272249
show ga
Abscisic acid (ABA) and gibberellic acid (GA) antagonistically regulate many
developmental processes and responses to biotic or abiotic stresses in higher
plants. However, the molecular mechanism underlying this antagonism is still
poorly understood. Here, we show that loss-of-function mutation in rice Tiller
Enhancer (TE), an activator of the APC/C(TE) complex, causes hypersensitivity and
hyposensitivity to ABA and GA, respectively. We find that TE physically interacts
with ABA receptor OsPYL/RCARs and promotes their degradation by the proteasome.
Genetic analysis also shows OsPYL/RCARs act downstream of TE in mediating ABA
responses. Conversely, ABA inhibits APC/C(TE) activity by phosphorylating TE
through activating the SNF1-related protein kinases (SnRK2s), which may interrupt
the interaction between TE and OsPYL/RCARs and subsequently stabilize
OsPYL/RCARs. In contrast, GA can reduce the level of SnRK2s and may promote
APC/C(TE)-mediated degradation of OsPYL/RCARs. Thus, we propose that the
SnRK2-APC/C(TE) regulatory module represents a regulatory hub underlying the
antagonistic action of GA and ABA in plants.