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"Ziziphus jujuba": A red fruit with promising anticancer activities
#MMPMID26392706
Tahergorabi Z
; Abedini MR
; Mitra M
; Fard MH
; Beydokhti H
Pharmacogn Rev
2015[Jul]; 9
(18
): 99-106
PMID26392706
show ga
Ziziphus jujuba Mill. (Z. jujuba) is a traditional herb with a long history of
use for nutrition and the treatment of a broad spectrum of diseases. It grows
mostly in South and East Asia, as well as in Australia and Europe. Mounting
evidence shows the health benefits of Z. jujuba, including anticancer,
anti-inflammation, antiobesity, antioxidant, and hepato- and gastrointestinal
protective properties, which are due to its bioactive compounds. Chemotherapy,
such as with cis-diamminedichloroplatinium (CDDP, cisplatin) and its derivatives,
is widely used in cancer treatment. It is an effective treatment for human
cancers, including ovarian cancer; however, drug resistance is a major obstacle
to successful treatment. A better understanding of the mechanisms and strategies
for overcoming chemoresistance can greatly improve therapeutic outcomes for
patients. In this review article, the bioactive compounds present in Z. jujuba
are explained. The high prevalence of many different cancers worldwide has
recently attracted the attention of many researchers. This is why our research
group focused on studying the anticancer activity of Z. jujuba as well as its
impact on chemoresistance both in vivo and in vitro. We hope that these studies
can lead to a promising future for cancer patients.
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