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10.1038/ncomms8967 http://scihub22266oqcxt.onion/10.1038/ncomms8967 C4557123!4557123!26284939     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26284939|t=2015. Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer s disease pathology |pdf=|usr=}}{{26284939}} gab.com Text Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer s disease pathology JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26284939 #FOAvip Alzheimer's disease (AD) is a neurodegenerative disorder in which chronic neuroinflammation contributes to disease escalation. Nevertheless, while immunosuppressive drugs have repeatedly failed in treating this disease, recruitment of myeloid cells to the CNS was shown to play a reparative role in animal models. Here we show, using the 5XFAD AD mouse model, that transient depletion of Foxp3+ regulatory T cells (Tregs), or pharmacological inhibition of their activity, is followed by amyloid-? plaque clearance, mitigation of the neuroinflammatory response and reversal of cognitive decline. We further show that transient Treg depletion affects the brain's choroid plexus, a selective gateway for immune cell trafficking to the CNS, and is associated with subsequent recruitment of immunoregulatory cells, including monocyte-derived macrophages and Tregs, to cerebral sites of plaque pathology. Our findings suggest targeting Treg-mediated systemic immunosuppression for treating AD. Twit Text FOAVip Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer s disease pathology ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26284939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26284939 #FOAvip English Wikipedia <ref>{{Cite pmid|26284939}}</ref> Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer s disease pathology #MMPMID26284939 Baruch K; Rosenzweig N; Kertser A; Deczkowska A; Sharif AM; Spinrad A; Tsitsou-Kampeli A; Sarel A; Cahalon L; Schwartz M Nat Commun 2015[]; 6 (ä): ä PMID26284939show ga Alzheimer's disease (AD) is a neurodegenerative disorder in which chronic neuroinflammation contributes to disease escalation. Nevertheless, while immunosuppressive drugs have repeatedly failed in treating this disease, recruitment of myeloid cells to the CNS was shown to play a reparative role in animal models. Here we show, using the 5XFAD AD mouse model, that transient depletion of Foxp3+ regulatory T cells (Tregs), or pharmacological inhibition of their activity, is followed by amyloid-? plaque clearance, mitigation of the neuroinflammatory response and reversal of cognitive decline. We further show that transient Treg depletion affects the brain's choroid plexus, a selective gateway for immune cell trafficking to the CNS, and is associated with subsequent recruitment of immunoregulatory cells, including monocyte-derived macrophages and Tregs, to cerebral sites of plaque pathology. Our findings suggest targeting Treg-mediated systemic immunosuppression for treating AD. äBreaking immune tolerance by targeting Foxp3+ regulatory T cells mitig(epmc).pdf DeepDyve Pubget Overpricing