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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Urol
2015 ; 2015
(ä): 350324
Nephropedia Template TP
gab.com Text
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English Wikipedia
High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of
Localized Prostate Cancer: A Matched-Pair Analysis
#MMPMID26357511
Aoun F
; Limani K
; Peltier A
; Marcelis Q
; Zanaty M
; Chamoun A
; Vanden Bossche M
; Roumegučre T
; van Velthoven R
Adv Urol
2015[]; 2015
(ä): 350324
PMID26357511
show ga
Purpose. To evaluate postoperative morbidity and long term oncologic and
functional outcomes of high intensity focused ultrasound (HIFU) compared to
brachytherapy for the treatment of localized prostate cancer. Material and
Methods. Patients treated by brachytherapy were matched 1?:?1 with patients who
underwent HIFU. Differences in postoperative complications across the two groups
were assessed using Wilcoxon's rank-sum or ? (2) test. Kaplan-Meier curves,
log-rank tests, and Cox regression models were constructed to assess differences
in survival rates between the two groups. Results. Brachytherapy was
significantly associated with lower voiding LUTS and less frequent acute urinary
retention (p < 0.05). Median oncologic follow-up was 83 months (13-123 months) in
the HIFU cohort and 44 months (13-89 months) in the brachytherapy cohort. Median
time to achieve PSA nadir was statistically shorter in the HIFU. Biochemical
recurrence-free survival rate was significantly higher in the brachytherapy
cohort compared to HIFU cohort (68.5% versus 53%, p < 0.05). No statistically
significant difference in metastasis-free, cancer specific, and overall survivals
was observed between the two groups. Conclusion. HIFU and brachytherapy are safe
with no significant difference in cancer specific survival on long term oncologic
follow-up. Nonetheless, a randomized controlled trial is needed to confirm these
results.