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10.1016/j.nicl.2015.07.015 http://scihub22266oqcxt.onion/10.1016/j.nicl.2015.07.015 C4556734!4556734!26413477     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuroimage+Clin 2015 ; 9 (ä): 140-52 Nephropedia Template TP {{tp|p=26413477|t=2015. Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |pdf=|usr=}}{{26413477}} gab.com Text Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents JO: Neuroimage Clin http://www.kidney.de/pget.php?&tw=1&pmid=26413477 #FOAvip Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs). We studied well-matched groups of adolescent males with autism, genetically-related siblings of individuals with autism, and typically-developing control participants. We parcellated the brain into 258 regions and used complex-network analysis to detect a robust hypoconnectivity endophenotype in our participant group. We observed that whole-brain functional connectivity was highest in controls, intermediate in siblings, and lowest in ASC, in task and rest conditions. We identified additional, local endophenotype effects in specific networks including the visual processing and default mode networks. Our analyses are the first to show that whole-brain functional hypoconnectivity is an endophenotype of autism in adolescence, and may thus underlie the heritable similarities seen in adolescents with ASC and their relatives. Twit Text FOAVip Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents ????Neuroimage Clin http://www.kidney.de/pget.php?&tw=1&pmid=26413477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26413477 #FOAvip English Wikipedia <ref>{{Cite pmid|26413477}}</ref> Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents #MMPMID26413477 Moseley R; Ypma R; Holt R; Floris D; Chura L; Spencer M; Baron-Cohen S; Suckling J; Bullmore E; Rubinov M Neuroimage Clin 2015[]; 9 (ä): 140-52 PMID26413477show ga Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs). We studied well-matched groups of adolescent males with autism, genetically-related siblings of individuals with autism, and typically-developing control participants. We parcellated the brain into 258 regions and used complex-network analysis to detect a robust hypoconnectivity endophenotype in our participant group. We observed that whole-brain functional connectivity was highest in controls, intermediate in siblings, and lowest in ASC, in task and rest conditions. We identified additional, local endophenotype effects in specific networks including the visual processing and default mode networks. Our analyses are the first to show that whole-brain functional hypoconnectivity is an endophenotype of autism in adolescence, and may thus underlie the heritable similarities seen in adolescents with ASC and their relatives. äWhole-brain functional hypoconnectivity as an endophenotype of autism (epmc).pdf DeepDyve Pubget Overpricing