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10.1371/journal.pone.0136923 http://scihub22266oqcxt.onion/10.1371/journal.pone.0136923 C4556704!4556704!26327228     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP {{tp|p=26327228|t=2015. Prion Protein Protects against Renal Ischemia/Reperfusion Injury |pdf=|usr=}}{{26327228}} gab.com Text Prion Protein Protects against Renal Ischemia/Reperfusion Injury JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26327228 #FOAvip The cellular prion protein (PrPC), a protein most noted for its link to prion diseases, has been found to play a protective role in ischemic brain injury. To investigate the role of PrPC in the kidney, an organ highly prone to ischemia/reperfusion (IR) injury, we examined wild-type (WT) and PrPC knockout (KO) mice that were subjected to 30-min of renal ischemia followed by 1, 2, or 3 days of reperfusion. Renal dysfunction and structural damage was more severe in KO than in WT mice. While PrP was undetectable in KO kidneys, Western blotting revealed an increase in PrP in IR-injured WT kidneys compared to sham-treated kidneys. Compared to WT, KO kidneys exhibited increases in oxidative stress markers heme oxygenase-1, nitrotyrosine, and N?-(carboxymethyl)lysine, and decreases in mitochondrial complexes I and III. Notably, phosphorylated extracellular signal-regulated kinase (pERK) staining was predominantly observed in tubular cells from KO mice following 2 days of reperfusion, a time at which significant differences in renal dysfunction, histological changes, oxidative stress, and mitochondrial complexes between WT and KO mice were observed. Our study provides the first evidence that PrPC may play a protective role in renal IR injury, likely through its effects on mitochondria and ERK signaling pathways. Twit Text FOAVip Prion Protein Protects against Renal Ischemia/Reperfusion Injury ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26327228 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26327228 #FOAvip English Wikipedia <ref>{{Cite pmid|26327228}}</ref> Prion Protein Protects against Renal Ischemia/Reperfusion Injury #MMPMID26327228 Zhang B; Cowden D; Zhang F; Yuan J; Siedlak S; Abouelsaad M; Zeng L; Zhou X; O'Toole J; Das AS; Kofskey D; Warren M; Bian Z; Cui Y; Tan T; Kresak A; Wyza RE; Petersen RB; Wang GX; Kong Q; Wang X; Sedor J; Zhu X; Zhu H; Zou WQ PLoS One 2015[]; 10 (9): ä PMID26327228show ga The cellular prion protein (PrPC), a protein most noted for its link to prion diseases, has been found to play a protective role in ischemic brain injury. To investigate the role of PrPC in the kidney, an organ highly prone to ischemia/reperfusion (IR) injury, we examined wild-type (WT) and PrPC knockout (KO) mice that were subjected to 30-min of renal ischemia followed by 1, 2, or 3 days of reperfusion. Renal dysfunction and structural damage was more severe in KO than in WT mice. While PrP was undetectable in KO kidneys, Western blotting revealed an increase in PrP in IR-injured WT kidneys compared to sham-treated kidneys. Compared to WT, KO kidneys exhibited increases in oxidative stress markers heme oxygenase-1, nitrotyrosine, and N?-(carboxymethyl)lysine, and decreases in mitochondrial complexes I and III. Notably, phosphorylated extracellular signal-regulated kinase (pERK) staining was predominantly observed in tubular cells from KO mice following 2 days of reperfusion, a time at which significant differences in renal dysfunction, histological changes, oxidative stress, and mitochondrial complexes between WT and KO mice were observed. Our study provides the first evidence that PrPC may play a protective role in renal IR injury, likely through its effects on mitochondria and ERK signaling pathways. äPrion Protein Protects against Renal Ischemia/Reperfusion Injury (epmc).pdf DeepDyve Pubget Overpricing