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2011 ; 26
(3
): 141-52
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-The advancement of biomarker-based diagnostic tools for ovarian, breast, and
pancreatic cancer through the use of urine as an analytical biofluid
#MMPMID21928247
Nolen BM
; Lokshin AE
Int J Biol Markers
2011[Jul]; 26
(3
): 141-52
PMID21928247
show ga
Despite considerable advancements, the development of effective cancer screening
tools based on serum biomarker measurements has thus far failed to achieve a
meaningful clinical impact. The incremental progress observed over the course of
serum biomarker development suggests that further refinements based on novel
approaches may yet result in a breakthrough. The use of urine as an analytical
biofluid for biomarker development may represent such an approach. The unique
characteristics of urine including a high level of stability, ease of sampling,
and an inactive and low-complexity testing matrix offer several potential
advantages over the use of serum. A number of recent reports have demonstrated
the utility of urine in the identification of novel cancer biomarkers and also
the improved performance of biomarkers previously evaluated in serum. In this
review, advancements related to the use of urine biomarkers within the settings
of ovarian, breast, and pancreatic cancer are presented and discussed. Findings
regarding the identification of specific urine biomarkers for each disease are
highlighted along with comparative analyses of urine and serum biomarkers as
diagnostic tools.