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2015 ; 10
(9
): e0136981
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The Anti-Proliferative Effect of Boron Neutron Capture Therapy in a Prostate
Cancer Xenograft Model
#MMPMID26325195
Takahara K
; Inamoto T
; Minami K
; Yoshikawa Y
; Takai T
; Ibuki N
; Hirano H
; Nomi H
; Kawabata S
; Kiyama S
; Miyatake S
; Kuroiwa T
; Suzuki M
; Kirihata M
; Azuma H
PLoS One
2015[]; 10
(9
): e0136981
PMID26325195
show ga
PURPOSE: Boron neutron capture therapy (BNCT) is a selective radiation treatment
for tumors that preferentially accumulate drugs carrying the stable boron
isotope, 10B. BNCT has been evaluated clinically as an alternative to
conventional radiation therapy for the treatment of brain tumors, and more
recently, recurrent advanced head and neck cancer. Here we investigated the
effect of BNCT on prostate cancer (PCa) using an in vivo mouse xenograft model
that we have developed. MATERIALS AND METHODS: Mice bearing the xenotransplanted
androgen-independent human PCa cell line, PC3, were divided into four groups:
Group 1: untreated controls; Group 2: Boronophenylalanine (BPA); Group 3:
neutron; Group 4: BPA-mediated BNCT. We compared xenograft growth among these
groups, and the body weight and any motility disturbance were recorded.
Immunohistochemical (IHC) studies of the proliferation marker, Ki-67, and TUNEL
staining were performed 9 weeks after treatment. RESULTS: The in vivo studies
demonstrated that BPA-mediated BNCT significantly delayed tumor growth in
comparison with the other groups, without any severe adverse events. There was a
significant difference in the rate of freedom from gait abnormalities between the
BPA-mediated BNCT group and the other groups. The IHC studies revealed that BNCT
treatment significantly reduced the number of Ki-67-positive cells in comparison
with the controls (mean ± SD 6.9 ± 1.5 vs 12.7 ± 4.0, p<0.05), while there was no
difference in the number of apoptotic cells, suggesting that BPA-mediated BNCT
reduced PCa progression without affecting apoptosis at 9 weeks post-treatment.
CONCLUSIONS: This study has provided the first preclinical proof-of-principle
data to indicate that BPA-mediated BNCT reduces the in vivo growth of PCa.
Although further studies will be necessary, BNCT might be a novel potential
treatment for PCa.
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