Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/bph.13212 http://scihub22266oqcxt.onion/10.1111/bph.13212 C4556471!4556471!26040667     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2015 ; 172 (17): 4331-41 Nephropedia Template TP {{tp|p=26040667|t=2015. Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice |pdf=|usr=}}{{26040667}} gab.com Text Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26040667 #FOAvip Background and Purpose: The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain. In this study we examined whether two analogues of Salvinorin A, PR-37 and PR-38, exhibit antipruritic properties in mice. Experimental Approach: To examine the antiscratch effect of PR-37 and PR-38 we used a mouse model of compound 48/80-induced pruritus. In order to elucidate the mechanism of action of tested compounds, specific antagonists of opioid and cannabinoid receptors were used. The effect of PR-37 on the CNS was assessed by measuring motor parameters and exploratory behaviours in mice. Key Results: PR-37 and PR-38, jnjected s.c., significantly reduced the number of compound 48/80-induced scratching behaviours in mice in a dose- and time-dependent manner. PR-38 was also active when orally administered. The antiscratch activity of PR-37 was blocked by the selective ? opioid receptor antagonist, nor-binaltorphimine, and that of PR-38 by the selective ? opioid receptor antagonist, ?-funaltrexamine. Conclusion and Implications: In conclusion, a novel framework for the development of new antipruritic drugs derived from salvinorin A has been validated. Twit Text FOAVip Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26040667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26040667 #FOAvip English Wikipedia <ref>{{Cite pmid|26040667}}</ref> Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice #MMPMID26040667 Salaga M; Polepally PR; Zielinska M; Marynowski M; Fabisiak A; Murawska N; Sobczak K; Sacharczuk M; Do Rego JC; Roth BL; Zjawiony JK; Fichna J Br J Pharmacol 2015[Sep]; 172 (17): 4331-41 PMID26040667show ga Background and Purpose: The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain. In this study we examined whether two analogues of Salvinorin A, PR-37 and PR-38, exhibit antipruritic properties in mice. Experimental Approach: To examine the antiscratch effect of PR-37 and PR-38 we used a mouse model of compound 48/80-induced pruritus. In order to elucidate the mechanism of action of tested compounds, specific antagonists of opioid and cannabinoid receptors were used. The effect of PR-37 on the CNS was assessed by measuring motor parameters and exploratory behaviours in mice. Key Results: PR-37 and PR-38, jnjected s.c., significantly reduced the number of compound 48/80-induced scratching behaviours in mice in a dose- and time-dependent manner. PR-38 was also active when orally administered. The antiscratch activity of PR-37 was blocked by the selective ? opioid receptor antagonist, nor-binaltorphimine, and that of PR-38 by the selective ? opioid receptor antagonist, ?-funaltrexamine. Conclusion and Implications: In conclusion, a novel framework for the development of new antipruritic drugs derived from salvinorin A has been validated. äSalvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induce(epmc).pdf DeepDyve Pubget Overpricing