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10.1016/j.devcel.2010.12.006 http://scihub22266oqcxt.onion/10.1016/j.devcel.2010.12.006 C4556435!4556435!21316594     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2011 ; 20 (2): 271-8 Nephropedia Template TP {{tp|p=21316594|t=2011. Mechanistic basis of otolith formation during teleost inner ear development |pdf=|usr=}}{{21316594}} gab.com Text Mechanistic basis of otolith formation during teleost inner ear development JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=21316594 #FOAvip Otoliths, which are connected to stereociliary bundles in the inner ear, serve as inertial sensors for balance. In teleostei, otolith development is critically dependant on flow forces generated by beating cilia; however, the mechanism by which flow controls otolith formation remains unclear. Here, we have developed a non-invasive flow probe using optical tweezers and a viscous flow model in order to demonstrate how the observed hydrodynamics influence otolith assembly. We show that rotational flow stirs and suppresses precursor agglomeration in the core of the cilia-driven vortex. The velocity field correlates with the shape of the otolith and we provide evidence that hydrodynamics is actively involved in controlling otolith morphogenesis. An implication of this hydrodynamic effect is that otolith self-assembly is mediated by the balance between Brownian motion and cilia-driven flow. More generally, this flow feature highlights an alternative biological strategy for controlling particle localization in solution. Twit Text FOAVip Mechanistic basis of otolith formation during teleost inner ear development ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=21316594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21316594 #FOAvip English Wikipedia <ref>{{Cite pmid|21316594}}</ref> Mechanistic basis of otolith formation during teleost inner ear development #MMPMID21316594 Wu D; Freund JB; Fraser SE; Vermot J Dev Cell 2011[Feb]; 20 (2): 271-8 PMID21316594show ga Otoliths, which are connected to stereociliary bundles in the inner ear, serve as inertial sensors for balance. In teleostei, otolith development is critically dependant on flow forces generated by beating cilia; however, the mechanism by which flow controls otolith formation remains unclear. Here, we have developed a non-invasive flow probe using optical tweezers and a viscous flow model in order to demonstrate how the observed hydrodynamics influence otolith assembly. We show that rotational flow stirs and suppresses precursor agglomeration in the core of the cilia-driven vortex. The velocity field correlates with the shape of the otolith and we provide evidence that hydrodynamics is actively involved in controlling otolith morphogenesis. An implication of this hydrodynamic effect is that otolith self-assembly is mediated by the balance between Brownian motion and cilia-driven flow. More generally, this flow feature highlights an alternative biological strategy for controlling particle localization in solution. äMechanistic basis of otolith formation during teleost inner ear develo(epmc).pdf DeepDyve Pubget Overpricing