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10.1111/j.1462-2920.2010.02357.x http://scihub22266oqcxt.onion/10.1111/j.1462-2920.2010.02357.x C4556285!4556285!20946586     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Environ+Microbiol 2011 ; 13 (3): 563-75 Nephropedia Template TP {{tp|p=20946586|t=2011. ppGpp is the major source of growth rate control in E coli |pdf=|usr=}}{{20946586}} gab.com Text ppGpp is the major source of growth rate control in E coli JO: Environ Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=20946586 #FOAvip It is widely accepted that the DNA, RNA and protein content of Enterobacteriaceae is regulated as a function of exponential growth rates; macromolecular content increases with faster growth regardless of specific composition of the growth medium. This phenomenon, called growth rate control, primarily involves regulation of ribosomal RNA and ribosomal protein synthesis. However, it was uncertain whether the global regulator ppGpp is the major determinant for growth rate control. Therefore, here we re-evaluate the effect of ppGpp on macromolecular content for different balanced growth rates in defined media. We find that when ppGpp is absent RNA/protein and RNA/DNA ratios are equivalent in fast and slow growing cells. Moreover, slow growing ppGpp deficient cells with increased RNA content, display a normal ribosomal subunit composition although polysome content is reduced when compared to fast growing wild type cells. From this we conclude that growth rate control does not occur in the absence of ppGpp. Also, artificial elevation of ppGpp or introduction of stringent RNA polymerase mutants in ppGpp deficient cells restores this control. We believe these findings strongly argue in favor of ppGpp and against redundant regulation of growth rate control by other factors in E. coli and other enteric bacteria. Twit Text FOAVip ppGpp is the major source of growth rate control in E coli ????Environ Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=20946586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20946586 #FOAvip English Wikipedia <ref>{{Cite pmid|20946586}}</ref> ppGpp is the major source of growth rate control in E coli #MMPMID20946586 Potrykus K; Murphy H; Philippe N; Cashel M Environ Microbiol 2011[Mar]; 13 (3): 563-75 PMID20946586show ga It is widely accepted that the DNA, RNA and protein content of Enterobacteriaceae is regulated as a function of exponential growth rates; macromolecular content increases with faster growth regardless of specific composition of the growth medium. This phenomenon, called growth rate control, primarily involves regulation of ribosomal RNA and ribosomal protein synthesis. However, it was uncertain whether the global regulator ppGpp is the major determinant for growth rate control. Therefore, here we re-evaluate the effect of ppGpp on macromolecular content for different balanced growth rates in defined media. We find that when ppGpp is absent RNA/protein and RNA/DNA ratios are equivalent in fast and slow growing cells. Moreover, slow growing ppGpp deficient cells with increased RNA content, display a normal ribosomal subunit composition although polysome content is reduced when compared to fast growing wild type cells. From this we conclude that growth rate control does not occur in the absence of ppGpp. Also, artificial elevation of ppGpp or introduction of stringent RNA polymerase mutants in ppGpp deficient cells restores this control. We believe these findings strongly argue in favor of ppGpp and against redundant regulation of growth rate control by other factors in E. coli and other enteric bacteria. äppGpp is the major source of growth rate control in E coli (epmc).pdf DeepDyve Pubget Overpricing