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2015 ; 2015
(ä): 698169
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Systems Medicine: The Application of Systems Biology Approaches for Modern
Medical Research and Drug Development
#MMPMID26357572
Ayers D
; Day PJ
Mol Biol Int
2015[]; 2015
(ä): 698169
PMID26357572
show ga
The exponential development of highly advanced scientific and medical research
technologies throughout the past 30 years has arrived to the point where the high
number of characterized molecular agents related to pathogenesis cannot be
readily integrated or processed by conventional analytical approaches. Indeed,
the realization that several moieties are signatures of disease has partly led to
the increment of complex diseases being characterized. Scientists and clinicians
can now investigate and analyse any individual dysregulations occurring within
the genomic, transcriptomic, miRnomic, proteomic, and metabolomic levels thanks
to currently available advanced technologies. However, there are drawbacks within
this scientific brave new age in that only isolated molecular levels are
individually investigated for their influence in affecting any particular health
condition. Since their conception in 1992, systems biology/medicine focuses
mainly on the perturbations of overall pathway kinetics for the consequent onset
and/or deterioration of the investigated condition/s. Systems medicine approaches
can therefore be employed for shedding light in multiple research scenarios,
ultimately leading to the practical result of uncovering novel dynamic
interaction networks that are critical for influencing the course of medical
conditions. Consequently, systems medicine also serves to identify clinically
important molecular targets for diagnostic and therapeutic measures against such
a condition.