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http://scihub22266oqcxt.onion/ C4555782!4555782!26339454     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Exp+Pathol 2015 ; 8 (7): 8663-70 Nephropedia Template TP {{tp|p=26339454|t=2015. Podoplanin increases migration and angiogenesis in malignant glioma |pdf=|usr=}}{{26339454}} gab.com Text Podoplanin increases migration and angiogenesis in malignant glioma JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26339454 #FOAvip Expression of podoplanin in glial brain tumors is grade dependent. While serving as a marker for tumor progression and modulating invasion in various neoplasms, little is known about podoplanin function in gliomas. Therefore we stably transfected two human glioma cell lines (U373MG and U87MG) with expression plasmids encoding podoplanin. The efficacy of transfection was confirmed by FACS analysis, PCR and immunocytochemistry. Cells were then sorted for highly podoplanin expressing cells (U373Phigh/U87Phigh). Transfection did not influence the production of pro-angiogenic factors including VEGF, VEGF-C and D. Also, expression of VEGF receptors (VEGFR) remained unchanged except for U87Phigh, where a VEGFR3 expression was induced. U373Phigh showed significantly reduced proliferation as compared to mock transfected group. By contrast, podoplanin significantly increased migration and invasion into collagen matrix. Furthermore, conditioned media from Phigh glioma cells strongly induced tube formation on matrigel. In conclusion, podoplanin increased migration of tumor cells and enhanced tube formation activity in endothelial cells independent from VEGF. Thus, podoplanin expression may be an important step in tumor progression. Twit Text FOAVip Podoplanin increases migration and angiogenesis in malignant glioma ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26339454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26339454 #FOAvip English Wikipedia <ref>{{Cite pmid|26339454}}</ref> Podoplanin increases migration and angiogenesis in malignant glioma #MMPMID26339454 Grau SJ; Trillsch F; Tonn JC; Goldbrunner RH; Noessner E; Nelson PJ; von Luettichau I Int J Clin Exp Pathol 2015[]; 8 (7): 8663-70 PMID26339454show ga Expression of podoplanin in glial brain tumors is grade dependent. While serving as a marker for tumor progression and modulating invasion in various neoplasms, little is known about podoplanin function in gliomas. Therefore we stably transfected two human glioma cell lines (U373MG and U87MG) with expression plasmids encoding podoplanin. The efficacy of transfection was confirmed by FACS analysis, PCR and immunocytochemistry. Cells were then sorted for highly podoplanin expressing cells (U373Phigh/U87Phigh). Transfection did not influence the production of pro-angiogenic factors including VEGF, VEGF-C and D. Also, expression of VEGF receptors (VEGFR) remained unchanged except for U87Phigh, where a VEGFR3 expression was induced. U373Phigh showed significantly reduced proliferation as compared to mock transfected group. By contrast, podoplanin significantly increased migration and invasion into collagen matrix. Furthermore, conditioned media from Phigh glioma cells strongly induced tube formation on matrigel. In conclusion, podoplanin increased migration of tumor cells and enhanced tube formation activity in endothelial cells independent from VEGF. Thus, podoplanin expression may be an important step in tumor progression. äPodoplanin increases migration and angiogenesis in malignant glioma (epmc).pdf DeepDyve Pubget Overpricing