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Pregnancy in Women with Systemic Lupus Erythematosus: A Retrospective Study of 83
Pregnancies at a Single Centre
#MMPMID26295404
Chen S
; Sun X
; Wu B
; Lian X
Int J Environ Res Public Health
2015[Aug]; 12
(8
): 9876-88
PMID26295404
show ga
OBJECTIVE: To evaluate the outcome of 80 pregnant women with systemic lupus
erythematosus (SLE) and explore the risk factors for lupus flare, obstetric
complications and fetal loss. METHODS: 83 pregnancies in 80 women were divided
into three groups. Group A: patients in remission for > 6 months before
pregnancy, proteinuria < 0.5 g per day, without renal failure and discontinuation
of cytotoxic drugs for > one year; Group B: patients with SLE disease activity in
the six months before pregnancy; Group C: patients with new onset SLE during
pregnancy. RESULTS: In group A, 76.47% pregnancies achieved full-term deliveries
and 80.39% achieved live born infants. In group B and C, the outcome was poor.
Among 62 patients (64 pregnancies) diagnosed as SLE before pregnancy, SLE flares
occurred in 27 (42.19%) pregnancies. SLE disease activity in the six months
before pregnancy was significantly associated with lupus flare (OR 5.00, 95% CI
1.14-21.87, p = 0.03) and fetal loss. New onset lupus during pregnancy was
independently associated with obstetric complications (OR 7.22, 95% CI
2.14-24.38, p = 0.001). CONCLUSIONS: The current study confirmed the previous
report that SLE should be considered a high risk of pregnancy. If pregnancy is
planned after remission for > 6 months, the favorable outcome can be achieved.
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