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10.1016/j.tcb.2015.04.003 http://scihub22266oqcxt.onion/10.1016/j.tcb.2015.04.003 C4555184!4555184!26045259     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Cell+Biol 2015 ; 25 (9): 523-32 Nephropedia Template TP {{tp|p=26045259|t=2015. Stem cell mechanobiology: diverse lessons from bone marrow |pdf=|usr=}}{{26045259}} gab.com Text Stem cell mechanobiology: diverse lessons from bone marrow JO: Trends Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26045259 #FOAvip A stem cell niche is defined by diverse chemical and physical features that influence whether a stem cell remains quiescent, divides, or differentiates. Here we review mechanical determinants that affect cell fate through actomyosin forces, nucleoskeleton remodeling, and mechanosensitive translocation of transcription factors. Current methods for physical characterization of tissue microenvironments are summarized together with efforts to recapitulate niche mechanics in culture. We focus on mesenchymal stem cells, particularly in osteogenesis and adipogenesis, and on blood stem cells ? both of which reside in mechanically diverse marrow microenvironments. Given the explosion of efforts with pluripotent stem cells, the evident mechanosensitivity of these clinically relevant, multipotent marrow cells underscores an increasing need to examine and understand in vivo and in vitro physical properties on length scales that cells sense. Twit Text FOAVip Stem cell mechanobiology: diverse lessons from bone marrow ????Trends Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26045259 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26045259 #FOAvip English Wikipedia <ref>{{Cite pmid|26045259}}</ref> Stem cell mechanobiology: diverse lessons from bone marrow #MMPMID26045259 Ivanovska IL; Shin JW; Swift J; Discher DE Trends Cell Biol 2015[Sep]; 25 (9): 523-32 PMID26045259show ga A stem cell niche is defined by diverse chemical and physical features that influence whether a stem cell remains quiescent, divides, or differentiates. Here we review mechanical determinants that affect cell fate through actomyosin forces, nucleoskeleton remodeling, and mechanosensitive translocation of transcription factors. Current methods for physical characterization of tissue microenvironments are summarized together with efforts to recapitulate niche mechanics in culture. We focus on mesenchymal stem cells, particularly in osteogenesis and adipogenesis, and on blood stem cells ? both of which reside in mechanically diverse marrow microenvironments. Given the explosion of efforts with pluripotent stem cells, the evident mechanosensitivity of these clinically relevant, multipotent marrow cells underscores an increasing need to examine and understand in vivo and in vitro physical properties on length scales that cells sense. äStem cell mechanobiology: diverse lessons from bone marrow (epmc).pdf DeepDyve Pubget Overpricing