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10.1016/j.humpath.2015.05.011 http://scihub22266oqcxt.onion/10.1016/j.humpath.2015.05.011 C4554947!4554947 !26138782     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26138782 &cmd=llinks): Failed to open stream: HTTP request failed! 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Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases |pdf=|usr=}}{{26138782 }} gab.com Text Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases JO: Hum Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26138782 #FOAvip Common variable immunodeficiency is a primary immunodeficiency of unknown etiology characterized by low serum immunoglobulin G, a decreased ability to make specific antibodies, and variable T-cell defects. Approximately 10-30% of patients with common variable immunodeficiency develop clinical evidence of a diffuse parenchymal lung disease with a constellation of histopathologic findings termed granulomatous and lymphocytic interstitial lung disease. In this study, we characterized the histologic and immunohistochemical features in a series of 16 cases diagnosed by open lung biopsy. Peribronchiolar and interstitial lymphocytic infiltration, granulomatous inflammation, and organizing pneumonia were consistent features; interstitial fibrosis with architectural remodeling was also found in a subgroup of patients. By immunohistochemistry, a predominance of CD4+ T lymphocytes with variable numbers of CD8+ T cells and B cells was present, with a striking absence of FOXP3-positive T-regulatory cells. This heretofore unrecognized immunohistochemical finding needs further investigation for a potential role in the pathogenesis of the condition. The presence of interstitial fibrosis with or without architectural remodeling in a subset of patients also needs additional study, for effect on prognosis. Twit Text FOAVip Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases ????Hum Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26138782 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26138782 #FOAvip English Wikipedia <ref>{{Cite pmid|26138782 }}</ref> Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases #MMPMID26138782 Rao N ; Mackinnon AC ; Routes JM Hum Pathol 2015[Sep]; 46 (9 ): 1306-14 PMID26138782 show ga Common variable immunodeficiency is a primary immunodeficiency of unknown etiology characterized by low serum immunoglobulin G, a decreased ability to make specific antibodies, and variable T-cell defects. Approximately 10-30% of patients with common variable immunodeficiency develop clinical evidence of a diffuse parenchymal lung disease with a constellation of histopathologic findings termed granulomatous and lymphocytic interstitial lung disease. In this study, we characterized the histologic and immunohistochemical features in a series of 16 cases diagnosed by open lung biopsy. Peribronchiolar and interstitial lymphocytic infiltration, granulomatous inflammation, and organizing pneumonia were consistent features; interstitial fibrosis with architectural remodeling was also found in a subgroup of patients. By immunohistochemistry, a predominance of CD4+ T lymphocytes with variable numbers of CD8+ T cells and B cells was present, with a striking absence of FOXP3-positive T-regulatory cells. This heretofore unrecognized immunohistochemical finding needs further investigation for a potential role in the pathogenesis of the condition. The presence of interstitial fibrosis with or without architectural remodeling in a subset of patients also needs additional study, for effect on prognosis. |*Immunohistochemistry [MESH] |Adult [MESH] |Biomarkers/analysis [MESH] |Biopsy [MESH] |Common Variable Immunodeficiency/*diagnosis/immunology/pathology [MESH] |Female [MESH] |Granuloma, Respiratory Tract/*diagnosis/immunology/pathology [MESH] |Humans [MESH] |Lung Diseases, Interstitial/*diagnosis/immunology/pathology [MESH] |Lung/*immunology/*pathology [MESH] |Lymphocyte Subsets/*immunology/pathology [MESH] |Male [MESH] |Middle Aged [MESH]Granulomatous and lymphocytic interstitial lung disease: a spectrum of(epmc).pdf DeepDyve Pubget Overpricing