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10.1098/rsob.150092 http://scihub22266oqcxt.onion/10.1098/rsob.150092 C4554925!4554925!26269429     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Open+Biol 2015 ; 5 (8): ä Nephropedia Template TP {{tp|p=26269429|t=2015. The roles of ERAS during cell lineage specification of mouse early embryonic development |pdf=|usr=}}{{26269429}} gab.com Text The roles of ERAS during cell lineage specification of mouse early embryonic development JO: Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=26269429 #FOAvip Eras encodes a Ras-like GTPase protein that was originally identified as an embryonic stem cell-specific Ras. ERAS has been known to be required for the growth of embryonic stem cells and stimulates somatic cell reprogramming, suggesting its roles on mouse early embryonic development. We now report a dynamic expression pattern of Eras during mouse peri-implantation development: its expression increases at the blastocyst stage, and specifically decreases in E7.5 mesoderm. In accordance with its expression pattern, the increased expression of Eras promotes cell proliferation through controlling AKT activation and the commitment from ground to primed state through ERK activation in mouse embryonic stem cells; and the reduced expression of Eras facilitates primitive streak and mesoderm formation through AKT inhibition during gastrulation. The expression of Eras is finely regulated to match its roles in mouse early embryonic development during which Eras expression is negatively regulated by the ?-catenin pathway. Thus, beyond its well-known role on cell proliferation, ERAS may also play important roles in cell lineage specification during mouse early embryonic development. Twit Text FOAVip The roles of ERAS during cell lineage specification of mouse early embryonic development ????Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=26269429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26269429 #FOAvip English Wikipedia <ref>{{Cite pmid|26269429}}</ref> The roles of ERAS during cell lineage specification of mouse early embryonic development #MMPMID26269429 Zhao ZA; Yu Y; Ma HX; Wang XX; Lu X; Zhai Y; Zhang X; Wang H; Li L Open Biol 2015[Aug]; 5 (8): ä PMID26269429show ga Eras encodes a Ras-like GTPase protein that was originally identified as an embryonic stem cell-specific Ras. ERAS has been known to be required for the growth of embryonic stem cells and stimulates somatic cell reprogramming, suggesting its roles on mouse early embryonic development. We now report a dynamic expression pattern of Eras during mouse peri-implantation development: its expression increases at the blastocyst stage, and specifically decreases in E7.5 mesoderm. In accordance with its expression pattern, the increased expression of Eras promotes cell proliferation through controlling AKT activation and the commitment from ground to primed state through ERK activation in mouse embryonic stem cells; and the reduced expression of Eras facilitates primitive streak and mesoderm formation through AKT inhibition during gastrulation. The expression of Eras is finely regulated to match its roles in mouse early embryonic development during which Eras expression is negatively regulated by the ?-catenin pathway. Thus, beyond its well-known role on cell proliferation, ERAS may also play important roles in cell lineage specification during mouse early embryonic development. äThe roles of ERAS during cell lineage specification of mouse early emb(epmc).pdf DeepDyve Pubget Overpricing