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10.1016/j.heares.2015.04.014 http://scihub22266oqcxt.onion/10.1016/j.heares.2015.04.014 C4554812!4554812 !26002688     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26002688 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue |pdf=|usr=}}{{26002688 }} gab.com Text Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue JO: Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=26002688 #FOAvip Recent animal work has suggested that cochlear synapses are more vulnerable than hair cells in both noise-induced and age-related hearing loss. This synaptopathy is invisible in conventional histopathological analysis, because cochlear nerve cell bodies in the spiral ganglion survive for years, and synaptic analysis requires special immunostaining or serial-section electron microscopy. Here, we show that the same quadruple-immunostaining protocols that allow synaptic counts, hair cell counts, neuronal counts and differentiation of afferent and efferent fibers in mouse can be applied to human temporal bones, when harvested within 9 h post-mortem and prepared as dissected whole mounts of the sensory epithelium and osseous spiral lamina. Quantitative analysis of five "normal" ears, aged 54-89 yrs, without any history of otologic disease, suggests that cochlear synaptopathy and the degeneration of cochlear nerve peripheral axons, despite a near-normal hair cell population, may be an important component of human presbycusis. Although primary cochlear nerve degeneration is not expected to affect audiometric thresholds, it may be key to problems with hearing in noise that are characteristic of declining hearing abilities in the aging ear. Twit Text FOAVip Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue ????Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=26002688 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26002688 #FOAvip English Wikipedia <ref>{{Cite pmid|26002688 }}</ref> Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue #MMPMID26002688 Viana LM ; O'Malley JT ; Burgess BJ ; Jones DD ; Oliveira CA ; Santos F ; Merchant SN ; Liberman LD ; Liberman MC Hear Res 2015[Sep]; 327 (ä): 78-88 PMID26002688 show ga Recent animal work has suggested that cochlear synapses are more vulnerable than hair cells in both noise-induced and age-related hearing loss. This synaptopathy is invisible in conventional histopathological analysis, because cochlear nerve cell bodies in the spiral ganglion survive for years, and synaptic analysis requires special immunostaining or serial-section electron microscopy. Here, we show that the same quadruple-immunostaining protocols that allow synaptic counts, hair cell counts, neuronal counts and differentiation of afferent and efferent fibers in mouse can be applied to human temporal bones, when harvested within 9 h post-mortem and prepared as dissected whole mounts of the sensory epithelium and osseous spiral lamina. Quantitative analysis of five "normal" ears, aged 54-89 yrs, without any history of otologic disease, suggests that cochlear synaptopathy and the degeneration of cochlear nerve peripheral axons, despite a near-normal hair cell population, may be an important component of human presbycusis. Although primary cochlear nerve degeneration is not expected to affect audiometric thresholds, it may be key to problems with hearing in noise that are characteristic of declining hearing abilities in the aging ear. |*Microscopy, Confocal [MESH] |*Nerve Degeneration [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Auditory Threshold [MESH] |Autopsy [MESH] |Axons/pathology [MESH] |Case-Control Studies [MESH] |Cochlea/*innervation [MESH] |Cochlear Nerve/chemistry/*pathology/physiopathology [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Hair Cells, Auditory/pathology [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Noise/adverse effects [MESH] |Perceptual Masking [MESH] |Presbycusis/metabolism/*pathology/physiopathology [MESH] |Spiral Ganglion/pathology [MESH] |Synapses/pathology [MESH]Cochlear neuropathy in human presbycusis: Confocal analysis of hidden (epmc).pdf DeepDyve Pubget Overpricing