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2015 ; 3
(4
): E318-22
Nephropedia Template TP
gab.com Text
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English Wikipedia
Lipid is absorbed in the stomach by epithelial neoplasms (adenomas and early
cancers): a novel functional endoscopy technique
#MMPMID26357677
Ohtsu K
; Yao K
; Matsunaga K
; Nagahama T
; Kanemitsu T
; Matsushima Y
; Yasaka M
; Ono Y
; Fujiwara S
; Hisabe T
; Takaki Y
; Hirai F
; Matsui T
; Hanada T
; Imamura K
; Tanabe H
; Iwashita A
; Shimokawa T
Endosc Int Open
2015[Aug]; 3
(4
): E318-22
PMID26357677
show ga
BACKGROUND AND STUDY AIMS: The authors have successfully demonstrated that the
white opaque substance (WOS) identified in gastric epithelial neoplasms is an
accumulation of minute lipid droplets on the epithelial neoplasm. It is not known
whether the lipid droplets originate from externally ingested lipids (typically
foods). The purpose of this study was to investigate whether the oral ingestion
of foods containing emulsified fats increases the density of the WOS in
epithelial neoplasms. PATIENTS AND METHODS: We examined 92 gastric epithelial
neoplastic lesions in 89 patients. The patients were given emulsified fatty foods
before the procedure, and magnifying endoscopy with narrow-band imaging (M-NBI)
was used to image the lesions. An increase in WOS density after the ingestion of
emulsified fatty foods was defined as a positive fat-loading test result. The
patients were divided into the following groups: control group, no emulsified fat
administered; group 1, fatty food administered 16 hours prior; group 3, fatty
food administered both 16 and 4 hours prior. The proportion of positive
fat-loading test results was determined in all groups. RESULTS: The rates of
positive fat-loading test results were as follows: control group, 9?%; group 1,
26?%; group 2, 52?%; group 3, 78?%. The increase in the rates of positive
fat-loading test results in groups 2 and 3 relative to the rate in the control
group was statistically significant (chi-squared test). CONCLUSIONS: This study
demonstrated for the first time that the ingestion of external lipids causes
lipid droplets to aggregate in situ on the gastric epithelial neoplasm. These
results can be used to develop a novel functional endoscopy technique that
harnesses the lipid absorption capacity of neoplasms.