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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Ophthalmol
2015 ; 9
(ä): 1537-41
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Submacular predominantly hemorrhagic choroidal neovascularization: resolution of
bleedings under anti-VEGF therapy
#MMPMID26346691
Dimopoulos S
; Leitritz MA
; Ziemssen F
; Voykov B
; Bartz-Schmidt KU
; Gelisken F
Clin Ophthalmol
2015[]; 9
(ä): 1537-41
PMID26346691
show ga
PURPOSE: To report the visual and morphological outcomes following intravitreal
bevacizumab in neovascular age-related macular degeneration (nAMD) with
submacular, predominantly hemorrhagic, lesions. METHODS: Retrospective study of
patients with a follow-up after 1 year. All eyes with submacular hemorrhages
larger than 50% of the total lesion size and received only anti-VEGF (vascular
endothelial growth factor) monotherapy (intravitreous administration of 1.25 mg
bevacizumab, PRN). The primary endpoint was the change in hemorrhage size and
time to resolution, in association with the mean best-corrected visual acuity
(BCVA). The eyes were grouped based on the size of the hemorrhage: group A (?1 to
<4 disc area [DA]), group B (?4 to <9 DA), and group C (?9 DA). RESULTS:
Forty-six consecutive eyes were included. The mean area of the hemorrhage was 6
DA at baseline. Eyes with smaller bleeding (group A) had better chances of
stabilized or improved vision. Complete resolution of the hemorrhage was seen in
96% of the eyes within 1 year. The mean BCVA increased from 0.81 logarithm of the
minimum angle of resolution (logMAR) (95% confidence interval [CI]: 0.70-0.92)
(Snellen 20/125) at baseline to 0.75 logMAR (95% CI: 0.62-0.88) (20/125) after 1
year (P=0.11). BCVA improved (one or more ETDRS [Early Treatment of Diabetic
Retinopathy Study] lines) in 57% of the eyes (13/23) in group A; 53% (8/15) in
group B; and 38% (3/8) in group C. CONCLUSION: Many of the eyes with hemorrhagic
lesions showed stabilization or improvement of the mean BCVA after treatment
within 1 year. Anti-VEGF treatment can be considered as a useful treatment option
in eyes with hemorrhages secondary to nAMD.