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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Invest+Ophthalmol+Vis+Sci
2015 ; 56
(2
): 918-31
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gab.com Text
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Advancing therapeutic strategies for inherited retinal degeneration:
recommendations from the Monaciano Symposium
#MMPMID25667399
Thompson DA
; Ali RR
; Banin E
; Branham KE
; Flannery JG
; Gamm DM
; Hauswirth WW
; Heckenlively JR
; Iannaccone A
; Jayasundera KT
; Khan NW
; Molday RS
; Pennesi ME
; Reh TA
; Weleber RG
; Zacks DN
Invest Ophthalmol Vis Sci
2015[Feb]; 56
(2
): 918-31
PMID25667399
show ga
Although rare in the general population, retinal dystrophies occupy a central
position in current efforts to develop innovative therapies for blinding
diseases. This status derives, in part, from the unique biology, accessibility,
and function of the retina, as well as from the synergy between molecular
discoveries and transformative advances in functional assessment and retinal
imaging. The combination of these factors has fueled remarkable progress in the
field, while at the same time creating complex challenges for organizing
collective efforts aimed at advancing translational research. The present
position paper outlines recent progress in gene therapy and cell therapy for this
group of disorders, and presents a set of recommendations for addressing the
challenges remaining for the coming decade. It is hoped that the formulation of
these recommendations will stimulate discussions among researchers, funding
agencies, industry, and policy makers that will accelerate the development of
safe and effective treatments for retinal dystrophies and related diseases.