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2015 ; 94
(30
): e1222
Nephropedia Template TP
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Acute Anticholinesterase Pesticide Poisoning Caused a Long-Term Mortality
Increase: A Nationwide Population-Based Cohort Study
#MMPMID26222853
Huang HS
; Hsu CC
; Weng SF
; Lin HJ
; Wang JJ
; Su SB
; Huang CC
; Guo HR
Medicine (Baltimore)
2015[Jul]; 94
(30
): e1222
PMID26222853
show ga
Acute anticholinesterase pesticide (organophosphate and carbamate) poisoning
(ACPP) often produces severe complications, and sometimes death. We investigated
the long-term mortality of patients with ACPP because it is not sufficiently
understood. In this retrospective nationwide population-based cohort study, 818
patients with ACPP and 16,360 healthy comparisons from 1999 to 2010 were selected
from Taiwan's National Health Insurance Research Database. They were followed
until 2011. Ninety-four (11.5%) ACPP patients and 793 (4.9%) comparisons died (P
< 0.01) during follow-up. The incidence rate ratios (IRRs) of death were 2.5
times higher in ACPP patients than in comparisons (P < 0.01). The risk of death
was particularly high in the first month after ACPP (IRR: 92.7; 95% confidence
interval [CI]: 45.0-191.0) and still high for ~6 months (IRR: 3.8; 95% CI:
1.9-7.4). After adjusting for age, gender, selected comorbidities, geographic
area, and monthly income, the hazard ratio of death for ACPP patients was still
2.4 times higher than for comparisons. Older age (?35 years), male gender,
diabetes mellitus, coronary artery disease, hypertension, stroke, mental
disorder, and lower monthly income also predicted death. ACPP significantly
increased long-term mortality. In addition to early follow-up after acute
treatment, comorbidity control and socioeconomic assistance are needed for
patients with ACPP.