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2015 ; 94
(30
): e1226
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Rosuvastatin Treatment for Preventing Contrast-Induced Acute Kidney Injury After
Cardiac Catheterization: A Meta-Analysis of Randomized Controlled Trials
#MMPMID26222855
Yang Y
; Wu YX
; Hu YZ
Medicine (Baltimore)
2015[Jul]; 94
(30
): e1226
PMID26222855
show ga
We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate
the protective effects of rosuvastatin on contrast-induced acute kidney injury
(CI-AKI) and major adverse cardiovascular events (MACEs) in patients undergoing
cardiac catherization.PubMed, MEDLINE, Web of Science, EMBASE,
ClinicalTrials.gov, and the Cochrane Central RCTs were searched for RCTs from
inception to May 2015, to compare rosuvastatin for preventing CI-AKI with placebo
treatment in patients undergoing cardiac catherization.Five RCTs with a total of
4045 patients involving 2020 patients pretreated with rosuvastatin and 2025
control patients were identified and analyzed. Patients treated with rosuvastatin
had a 51% lower risk of CI-AKI compared with the control group based on a
fixed-effect model (OR = 0.49, 95% CI = 0.37-0.66, P < 0.001), and showed a trend
toward a reduced risk of MACEs (OR = 0.62, 95% CI = 0.36-1.07, P = 0.08). A
subgroup analysis showed that studies with Jadad score ?3 showed a significant
reduction of CI-AKI (OR = 0.53, 95% CI, 0.38-0.73, P < 0.001). However, the risk
of CI-AKI did not significantly differ in the studies with Jadad score <3 (OR =
0.54, 95% CI, 0.13-2.24, P = 0.40). In addition, the rosuvastatin treatment
showed no effect for preventing CI-AKI in patients with chronic kidney disease
(CKD) undergoing elective cardiac catherization (I = 0%, OR = 0.81, 95% CI =
0.41-1.61, P = 0.55).This updated meta-analysis demonstrated that preprocedural
rosuvastatin treatment could significantly reduce the incidence of CI-AKI, with a
trend toward a reduced risk of MACEs in patients undergoing cardiac
catheterization. However, rosuvastatin treatment did not seem to be effective for
preventing CI-AKI in CKD patients undergoing elective cardiac catheterization.
|*Acute Kidney Injury/chemically induced/epidemiology/prevention & control
[MESH]