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10.1097/MD.0000000000000622

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C4554050!4554050!25860208
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suck abstract from ncbi


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pmid25860208      Medicine+(Baltimore) 2015 ; 94 (14): ä
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  • Management of Large-Vessel Vasculitis With FDG-PET: A Systematic Literature Review and Meta-Analysis #MMPMID25860208
  • Soussan M; Nicolas P; Schramm C; Katsahian S; Pop G; Fain O; Mekinian A
  • Medicine (Baltimore) 2015[Apr]; 94 (14): ä PMID25860208show ga
  • We aimed to clarify the role of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in the management of large-vessel vasculitis (LVV), focusing on 3 issues which are as follows: describe and determine the different FDG-PET criteria for the diagnosis of vascular inflammation, the performance of FDG-PET for the diagnosis of large-vessel inflammation in giant cell arteritis (GCA) patients, and the performance of FDG-PET to evaluate the disease inflammatory activity in Takayasu arteritis (TA) patients.MEDLINE, Cochrane Library, and EMBASE database were searched for articles that evaluated the value of FDG-PET in LVV, from January 2000 to December 2013. Inclusion criteria were American College of Rheumatology criteria for GCA or TA, definition PET positivity threshold, and >4 cases included. Sensitivity (Se) and specificity (Sp) of FDG-PET for the diagnosis of large-vessel inflammation were calculated from each included individual study, and then pooled for meta-analysis with a random-effects model.Twenty-one studies (413 patients, 299 controls) were included in the systematic review. FDG-PET showed FDG vascular uptake in 70% (288/413) of patients and 7% (22/299) of controls. Only vascular uptake equal to or higher than the liver uptake was significantly different between GCA/TA patients and controls (P?
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