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2015 ; 94
(13
): e727
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Nonintubated thoracoscopic lobectomy for lung cancer using epidural anesthesia
and intercostal blockade: a retrospective cohort study of 238 cases
#MMPMID25837768
Medicine (Baltimore)
2015[Apr]; 94
(13
): e727
PMID25837768
show ga
Intubated general anesthesia with single-lung ventilation has been considered
mandatory for thoracoscopic lobectomy for nonsmall cell lung cancer. Few reports
of thoracoscopic lobectomy without tracheal intubation are published, using
either thoracic epidural anesthesia (TEA) or intercostal blockade. The
comparisons of perioperative outcomes of nonintubated thoracoscopic lobectomy
using epidural anesthesia and intercostal blockade are not reported previously.
From September 2009 to August 2014, a total of 238 patients with lung cancer who
underwent nonintubated thoracoscopic lobectomy were recruited from our
prospectively maintained database of all patients undergoing nonintubated
thoracoscopic surgery using TEA or intercostal blockade. A multiple regression
analysis, adjusting for preoperative variables, was performed to compare the
perioperative outcomes of the 2 anesthesia methods. Overall, 130 patients
underwent nonintubated thoracoscopic lobectomy using epidural anesthesia whereas
108 had intercostal blockade. The 2 groups were similar in demographic data,
except for sex, preoperative lung function, physical status classification, and
history of smoking. After adjustment for the preoperative variables, nonintubated
thoracoscopic lobectomy using intercostal blockade was associated with shorter
durations of anesthetic induction and surgery (P?0.001). Furthermore,
hemodynamics were more stable with less use of vasoactive drugs (odds ratio:
0.53; 95% confidence interval [CI], 0.27 to 1.04; P?=?0.064) and less blood loss
(mean difference: -55.2?mL; 95% CI, -93 to -17.3; P?=?0.004). Postoperatively,
the 2 groups had comparable incidences of complications. Patients in the
intercostal blockade group had a shorter average duration of chest tube drainage
(P?=?0.064) but a similar average length of hospital stay (P?=?0.569). Conversion
to tracheal intubation was required in 13 patients (5.5%), and no in-hospital
mortality occurred in either group. Nonintubated thoracoscopic lobectomy using
either epidural anesthesia or intercostal blockade is feasible and safe.
Intercostal blockade is a simpler alternative to epidural anesthesia for
nonintubated thoracoscopic lobectomy in selected patients with lung cancer.