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10.1097/MD.0b013e3182899e78

http://scihub22266oqcxt.onion/10.1097/MD.0b013e3182899e78
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C4553982!4553982!23429351
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suck abstract from ncbi


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pmid23429351      Medicine+(Baltimore) 2013 ; 92 (2): 69-81
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  • Severe Aplastic Anemia Associated With Eosinophilic Fasciitis: Report of 4 Cases and Review of the Literature #MMPMID23429351
  • de Masson A; Bouaziz JD; de Latour RP; Benhamou Y; Moluçon-Chabrot C; Bay JO; Laquerrière A; Picquenot JM; Michonneau D; Leguy-Seguin V; Rybojad M; Bonnotte B; Jardin F; Lévesque H; Bagot M; Socié G
  • Medicine (Baltimore) 2013[Mar]; 92 (2): 69-81 PMID23429351show ga
  • Diffuse eosinophilic fasciitis (Shulman disease) is a rare sclerodermiform syndrome that, in most cases, resolves spontaneously or after corticosteroid therapy. It has been associated with hematologic disorders, such as aplastic anemia. The clinical features and long-term outcomes of patients with eosinophilic fasciitis and associated aplastic anemia have been poorly described. We report the cases of 4 patients with eosinophilic fasciitis and associated severe aplastic anemia. For 3 of these patients, aplastic anemia was refractory to conventional immunosuppressive therapy with antithymocyte globulin and cyclosporine. One of the patients received rituximab as a second-line therapy with significant efficacy for both the skin and hematologic symptoms. To our knowledge, this report is the first to describe rituximab used to treat eosinophilic fasciitis with associated aplastic anemia.In a literature review, we identified 19 additional cases of eosinophilic fasciitis and aplastic anemia. Compared to patients with isolated eosinophilic fasciitis, patients with eosinophilic fasciitis and associated aplastic anemia were more likely to be men (70%) and older (mean age, 56 yr; range, 18?71 yr). Corticosteroid-containing regimens improved skin symptoms in 5 (42%) of 12 cases but were ineffective in the treatment of associated aplastic anemia in all but 1 case. Aplastic anemia was profound in 13 cases (57%) and was the cause of death in 8 cases (35%). Only 5 patients (22%) achieved long-term remission (allogeneic hematopoietic stem cell transplantation: n = 2; cyclosporine-containing regimen: n = 2; high-dose corticosteroid-based regimen: n = 1).
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