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2015 ; 4
(ä): 27494
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Biogenesis, delivery, and function of extracellular RNA
#MMPMID26320939
Patton JG
; Franklin JL
; Weaver AM
; Vickers K
; Zhang B
; Coffey RJ
; Ansel KM
; Blelloch R
; Goga A
; Huang B
; L'Etoille N
; Raffai RL
; Lai CP
; Krichevsky AM
; Mateescu B
; Greiner VJ
; Hunter C
; Voinnet O
; McManus MT
J Extracell Vesicles
2015[]; 4
(ä): 27494
PMID26320939
show ga
The Extracellular RNA (exRNA) Communication Consortium was launched by the
National Institutes of Health to focus on the extent to which RNA might function
in a non-cell-autonomous manner. With the availability of increasingly sensitive
tools, small amounts of RNA can be detected in serum, plasma, and other bodily
fluids. The exact mechanism(s) by which RNA can be secreted from cells and the
mechanisms for the delivery and uptake by recipient cells remain to be
determined. This review will summarize current knowledge about the biogenesis and
delivery of exRNA and outline projects seeking to understand the functional
impact of exRNA.