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10.1530/EJE-15-0464 http://scihub22266oqcxt.onion/10.1530/EJE-15-0464 C4553096!4553096!26156970     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Endocrinol 2015 ; 173 (4): M33-8 Nephropedia Template TP {{tp|p=26156970|t=2015. Cushing s Syndrome: Update on signs, symptoms and biochemical screening |pdf=|usr=}}{{26156970}} gab.com Text Cushing s Syndrome: Update on signs, symptoms and biochemical screening JO: Eur J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26156970 #FOAvip Endogenous pathologic hypercortisolism, or Cushing?s syndrome, is associated with poor quality of life, morbidity and increased mortality. Early diagnosis may mitigate against this natural history of the disorder.The clinical presentation of Cushing?s syndrome varies, in part related to the extent and duration of cortisol excess. When hypercortisolism is severe, its signs and symptoms are unmistakable. However, most of the signs and symptoms of Cushing?s syndrome are common in the general population (e.g. hypertension and weight gain) and not all are present in every patient.In addition to classical features of glucocorticoid excess, such as proximal muscle weakness and wide purple striae, patients may present with the associated co-morbidities that are caused by hypercortisolism. These include cardiovascular disease, thromboembolic disease, psychiatric and cognitive deficits, and infections. As a result, internists and generalists must consider Cushing?s syndrome as a cause, and endocrinologists should search for and treat these co-morbidities.Recommended tests to screen for Cushing?s syndrome include 1 mg dexamethasone suppression, urine free cortisol and late night salivary cortisol. These may be slightly elevated in patients with physiologic hypercortisolism, which should be excluded, along with exogenous glucocorticoid use. Each screening test has caveats and the choice of tests should be individualized based on each patient?s characteristics and lifestyle.The objective of this review was to update the readership on the clinical and biochemical features of Cushing?s syndrome that are useful when evaluating patients for this diagnosis. Twit Text FOAVip Cushing s Syndrome: Update on signs, symptoms and biochemical screening ????Eur J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26156970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26156970 #FOAvip English Wikipedia <ref>{{Cite pmid|26156970}}</ref> Cushing s Syndrome: Update on signs, symptoms and biochemical screening #MMPMID26156970 Nieman LK Eur J Endocrinol 2015[Oct]; 173 (4): M33-8 PMID26156970show ga Endogenous pathologic hypercortisolism, or Cushing?s syndrome, is associated with poor quality of life, morbidity and increased mortality. Early diagnosis may mitigate against this natural history of the disorder.The clinical presentation of Cushing?s syndrome varies, in part related to the extent and duration of cortisol excess. When hypercortisolism is severe, its signs and symptoms are unmistakable. However, most of the signs and symptoms of Cushing?s syndrome are common in the general population (e.g. hypertension and weight gain) and not all are present in every patient.In addition to classical features of glucocorticoid excess, such as proximal muscle weakness and wide purple striae, patients may present with the associated co-morbidities that are caused by hypercortisolism. These include cardiovascular disease, thromboembolic disease, psychiatric and cognitive deficits, and infections. As a result, internists and generalists must consider Cushing?s syndrome as a cause, and endocrinologists should search for and treat these co-morbidities.Recommended tests to screen for Cushing?s syndrome include 1 mg dexamethasone suppression, urine free cortisol and late night salivary cortisol. These may be slightly elevated in patients with physiologic hypercortisolism, which should be excluded, along with exogenous glucocorticoid use. Each screening test has caveats and the choice of tests should be individualized based on each patient?s characteristics and lifestyle.The objective of this review was to update the readership on the clinical and biochemical features of Cushing?s syndrome that are useful when evaluating patients for this diagnosis. äCushing s Syndrome: Update on signs, symptoms and biochemical screenin(epmc).pdf DeepDyve Pubget Overpricing