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10.1159/000375161 http://scihub22266oqcxt.onion/10.1159/000375161 C4553081!4553081 !25792183     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25792183 &cmd=llinks): Failed to open stream: HTTP request failed! 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Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection |pdf=|usr=}}{{25792183 }} gab.com Text Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection JO: J Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=25792183 #FOAvip In patients with hepatitis C virus (HCV) infection, enhanced activity of indoleamine-2,3-dioxygenase 1 (IDO) has been reported. IDO - a tryptophan-catabolizing enzyme - has been considered as both an innate defence mechanism and an important regulator of the immune response. The molecular mechanism of IDO induction in HCV infection and its role in the antiviral immune response remain unknown. Using primary human hepatocytes, we show that HCV infection stimulates IDO expression. IDO gene induction was transient and coincided with the expression of types I and III interferons (IFNs) and IFN-stimulated genes in HCV-infected hepatocytes. Overexpression of hepatic IDO prior to HCV infection markedly impaired HCV replication in hepatocytes, suggesting that IDO limits the spread of HCV within the liver. siRNA-mediated IDO knock-down revealed that IDO functions as an IFN-mediated anti-HCV effector. Hepatic IDO was most potently induced by IFN-x03B3;, and ongoing HCV replication could significantly upregulate IDO expression. IRF1 (IFN-regulatory factor 1) and STAT1 (signal transducer and activator of transcription 1) regulated hepatic IDO expression. Hepatic IDO expression also had a significant inhibitory effect on CD4+ T-cell proliferation. Our data suggest that hepatic IDO plays a dual role during HCV infection by slowing down viral replication and also regulating host immune responses. Twit Text FOAVip Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection ????J Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=25792183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25792183 #FOAvip English Wikipedia <ref>{{Cite pmid|25792183 }}</ref> Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection #MMPMID25792183 Lepiller Q ; Soulier E ; Li Q ; Lambotin M ; Barths J ; Fuchs D ; Stoll-Keller F ; Liang TJ ; Barth H J Innate Immun 2015[]; 7 (5 ): 530-44 PMID25792183 show ga In patients with hepatitis C virus (HCV) infection, enhanced activity of indoleamine-2,3-dioxygenase 1 (IDO) has been reported. IDO - a tryptophan-catabolizing enzyme - has been considered as both an innate defence mechanism and an important regulator of the immune response. The molecular mechanism of IDO induction in HCV infection and its role in the antiviral immune response remain unknown. Using primary human hepatocytes, we show that HCV infection stimulates IDO expression. IDO gene induction was transient and coincided with the expression of types I and III interferons (IFNs) and IFN-stimulated genes in HCV-infected hepatocytes. Overexpression of hepatic IDO prior to HCV infection markedly impaired HCV replication in hepatocytes, suggesting that IDO limits the spread of HCV within the liver. siRNA-mediated IDO knock-down revealed that IDO functions as an IFN-mediated anti-HCV effector. Hepatic IDO was most potently induced by IFN-x03B3;, and ongoing HCV replication could significantly upregulate IDO expression. IRF1 (IFN-regulatory factor 1) and STAT1 (signal transducer and activator of transcription 1) regulated hepatic IDO expression. Hepatic IDO expression also had a significant inhibitory effect on CD4+ T-cell proliferation. Our data suggest that hepatic IDO plays a dual role during HCV infection by slowing down viral replication and also regulating host immune responses. |CD4-Positive T-Lymphocytes/*immunology [MESH] |Cell Proliferation/genetics [MESH] |Cells, Cultured [MESH] |Hepacivirus/*physiology [MESH] |Hepatitis C/*immunology [MESH] |Hepatocytes/*immunology/virology [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Immunosuppression Therapy [MESH] |Indoleamine-Pyrrole 2,3,-Dioxygenase/*metabolism [MESH] |Interferon Regulatory Factor-1/genetics/metabolism [MESH] |Interferons/genetics/metabolism [MESH] |RNA, Small Interfering/genetics [MESH] |STAT1 Transcription Factor/genetics/metabolism [MESH]Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase (epmc).pdf DeepDyve Pubget Overpricing