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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Trends+Biochem+Sci
2015 ; 40
(9
): 516-25
Nephropedia Template TP
gab.com Text
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English Wikipedia
Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular
signaling pathways
#MMPMID26254229
Liu X
; Kraus WL
; Bai X
Trends Biochem Sci
2015[Sep]; 40
(9
): 516-25
PMID26254229
show ga
Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established
mechanism to control the timing, rate, and possibly the magnitude of
transcriptional responses. Recent studies have shown that cellular signaling
pathways can regulate gene transcription and signaling outcomes by controlling
Pol II pausing in a wide array of biological systems. Identification of the
proteins and small molecules that affect the establishment and release of paused
Pol II is shedding new light on the mechanisms and biology of Pol II pausing.
This review focuses on the interplay between cellular signaling pathways and Pol
II pausing during normal development and under disease conditions.