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10.1016/j.tibs.2015.07.003

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suck abstract from ncbi


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pmid26254229
      Trends+Biochem+Sci 2015 ; 40 (9 ): 516-25
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  • Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways #MMPMID26254229
  • Liu X ; Kraus WL ; Bai X
  • Trends Biochem Sci 2015[Sep]; 40 (9 ): 516-25 PMID26254229 show ga
  • Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established mechanism to control the timing, rate, and possibly the magnitude of transcriptional responses. Recent studies have shown that cellular signaling pathways can regulate gene transcription and signaling outcomes by controlling Pol II pausing in a wide array of biological systems. Identification of the proteins and small molecules that affect the establishment and release of paused Pol II is shedding new light on the mechanisms and biology of Pol II pausing. This review focuses on the interplay between cellular signaling pathways and Pol II pausing during normal development and under disease conditions.
  • |Animals [MESH]
  • |Gene Expression Regulation/genetics/physiology [MESH]
  • |Humans [MESH]
  • |RNA Polymerase II/genetics/*metabolism [MESH]


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