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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Neurology 2015 ; 85 (9): 799-805 Nephropedia Template TP
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Risk factors for poor visual outcome in patients with idiopathic intracranial hypertension #MMPMID26245929
Wall M; Falardeau J; Fletcher WA; Granadier RJ; Lam BL; Longmuir RA; Patel AD; Bruce BB; He H; McDermott MP; Banik R; Kedhar S; Levin F; Feistmann J; Tai K; Yang A; Tobias K; Rivas M; Dominguez L; Perez V; Longmuir R; Thurtell M; Eden T; Kardon R; Lesser R; O?Neil Y; Heaton S; Gintowt N; Rudich D; Digre K; Warner J; Hart B; Wegner K; Carlstrom B; Allman S; Katz B; Haroldsen A; Lam BL; Pasol J; Rosa PR; Morante A; Verriotto J; Katz D; Asbury T; Gerwin R; Barnett M; Hamilton S; Tongco C; Gangadharan B; May E; Patel A; Farris B; Siatkowsk RM; Miller H; Bergman V; White K; O?Dell S; Andrezik J; Tytle T; Shindler K; Dupont J; Salvo R; Drossner S; Ward S; Lo J; Engelhard S; Windsor E; Khella S; Tamhankar M; Van Stavern G; Kambarian J; Van Stavern R; Civitelli K; Shepherd JB; Bruce BB; Biousse V; Newman NJ; Brower J; Curtis L; Vaphiades M; Searcey K; Kline L; McDonald R; Givre SJ; Hales T; Bye P; Fuller K; Carnes KM; James K; Ragland M; Chung SM; Govreau DM; Lind JT; Williams Z; O?Gara G; Steinmetz K; Perevich M; Skrine K; Carter E; Ramchandran R; Katz S; Criden M; Coman G; McGregor J; Inman A; Subramanian PS; Hoffman PN; Medura M; Michaele Hartnett M; Siddiqui M; Brown D; Arnold E; Boring J; Miller NR; Quiros P; Ramos S; Padilla M; Cisneros L; Kao A; Filipe Chicani C; Na K; Tang R; Frishman L; Cajavilca P; Newland S; Gantz L; Guillermo Prieto M; Pass A; Holdeman NR; Lee MS; Roemhild H; Elasky W; Holleschau A; Fissgus J; Walski J; Harrison A; Falardeau J; Hills W; Bryant C; Kim D; Armour R; Higginbotham L; Newman SA; Holbrook K; Cook LD; Bacon H; Beall J; Goddard T; Technician WH; Hamilton D; Lyon A; Fletcher W; Subramaniam S; Reimer J; Nickerson J; Costello F; Rismondo-Stankovich V; Flanagan M; Jensen A; Sibony P; Lavorna AM; Mladek M; Tenzler R; Honkanen R; Miller-Horn J; Krupp L; Rizzo J; Cestari D; Snebold N; Vatcher B; Matera C; Miretsky E; Oakley J; Dumser J; Alperen T; Baptista-Pires S; Bator U; Barrett B; Callahan C; Brett S; Zimmerman K; Grillo M; Capaccioli K; Tariq Bhatti M; Greene L; Santiago-Turla MC; McClain N; El-Dairi M; Schatz M; Carter JE; O?Connor P; Mojica D; Smith J; Trigo Y; Slayman Kellogg S; Martinez A; Comeau P; Sanchez A; McCarthy N; Perez COT E; Bazan C; Maitland C; Brooks HL; Gorsica R; Sherman B; Kramer J; Frohman L; Amanda R; Boschert K; Tu Yf; Rivera S; Turbin R; Hove Mt; Breen A; Simms C; Kemp M; Farmer J; Granadier R; Osentoski T; Cumming K; Lewis B; Stec L; Kattah JC; Pula J; Buttice MR; DuPage K; Cooley K; Beck J; Technician LB; Guede C; Mejico L; Ko M; Jubelt B; Grosso M; Chilton M; Lou Watson M; Moore J; Martin T; Everhart C; Fish J; Cooke L; Dickinson JP; Acierno MD; Watts R; Thomassie A; Rao A; Mary Chiasson T; Rucker JC; Hannigan C; Katz-Sand I; Rajguru D; Kedar S; Vega N; Morris S; Pearson A; Hanson M; Kovacs B; Weil R; Pi-Sunyer Steven Feldon X; Fisher W; Castillo D; Davis V; Fagan L; Hollar R; Keenan T; MacDowell P; Keltner J; Plumb K; Leming L; Werner JS; Harvey D; Johnson C; Keltner J; Werner JS; Plumb K; Leming L; Bausch J; Gao S; Tu X; He H; Watts A; Baker D; Constantinescu R; Helles K; McMullen N; Olsen B; Preston L; Snively V; Stoutenburg A; Friedman D; Ayanru OI; Moss EA; Patel P; Mills R; Maguire M; Hart W; Katz J; Kaufman D; McCarthy C; Selhorst J; Digre K; Corbett J; Miller NR; Mills R
Neurology 2015[Sep]; 85 (9): 799-805 PMID26245929show ga
Objectives:: Determine potential risk factors for progressive visual field loss in the Idiopathic Intracranial Hypertension Treatment Trial, a randomized placebo-controlled trial of acetazolamide in patients with idiopathic intracranial hypertension and mild visual loss concurrently receiving a low sodium, weight reduction diet. Methods:: Logistic regression and classification tree analyses were used to evaluate potential risk factors for protocol-defined treatment failure (>2 dB perimetric mean deviation [PMD] change in patients with baseline PMD ?2 to ?3.5 dB or >3 dB PMD change with baseline PMD ?3.5 to ?7 dB). Results:: Seven participants (6 on diet plus placebo) met criteria for treatment failure. The odds ratio for patients with grades III to V papilledema vs those with grades I and II was 8.66 (95% confidence interval [CI] 1.65??, p = 0.025). A 1-unit decrease in the number of letters correct on the ETDRS (Early Treatment Diabetic Retinopathy Study) chart at baseline was associated with an increase in the odds of treatment failure by a factor of 1.16 (95% CI 1.04?1.30, p = 0.005). Compared with female participants, the odds ratio for male participants was 26.21 (95% CI 1.61?433.00, p = 0.02). The odds of treatment failure were 10.59 times higher (95% CI 1.63?116.83, p = 0.010) for patients with >30 transient visual obscurations per month vs those with ?30 per month. Conclusions:: Male patients, those with high-grade papilledema, and those with decreased visual acuity at baseline were more likely to experience treatment failure. All but one of these patients were treated with diet alone. These patients should be monitored closely and be considered for aggressive treatment of their idiopathic intracranial hypertension.
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Neurology 2015 ; 85 (9): 799-805
