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10.1038/jp.2015.51

http://scihub22266oqcxt.onion/10.1038/jp.2015.51
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C4552605!4552605!25950918
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suck abstract from ncbi


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pmid25950918      J+Perinatol 2015 ; 35 (9): 755-62
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  • Depth of Bacterial Invasion in Resected Intestinal Tissue Predicts Mortality in Surgical Necrotizing Enterocolitis #MMPMID25950918
  • Remon JI; Amin SC; Mehendale SR; Rao R; Luciano AA; Garzon SA; Maheshwari A
  • J Perinatol 2015[Sep]; 35 (9): 755-62 PMID25950918show ga
  • Objective: Up to a third of all infants who develop necrotizing enterocolitis (NEC) require surgical resection of necrotic bowel. We hypothesized that the histopathological findings in surgically-resected bowel can predict the clinical outcome of these infants. Study design: We reviewed the medical records and archived pathology specimens from all patients who underwent bowel resection/autopsy for NEC at a regional referral center over a 10-year period. Pathology specimens were graded for the depth and severity of necrosis, inflammation, bacteria invasion, and pneumatosis, and histopathological findings were correlated with clinical outcomes. Results: We performed clinico-pathological analysis on 33 infants with confirmed NEC, of which 18 (54.5%) died. Depth of bacterial invasion in resected intestinal tissue predicted death from NEC (odds ratio 5.39 per unit change in the depth of bacterial invasion, 95% confidence interval 1.33-21.73). The presence of transmural necrosis and bacteria in the surgical margins of resected bowel was also associated with increased mortality. Conclusions: Depth of bacterial invasion in resected intestinal tissue predicts mortality in surgical NEC.
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