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10.1371/journal.pone.0136116 http://scihub22266oqcxt.onion/10.1371/journal.pone.0136116 C4552549!4552549 !26312490     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26312490 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (8 ): e0136116 Nephropedia Template TP {{tp|p=26312490 |t=2015. A Short Peptide That Mimics the Binding Domain of TGF-?1 Presents Potent Anti-Inflammatory Activity |pdf=|usr=}}{{26312490 }} gab.com Text A Short Peptide That Mimics the Binding Domain of TGF- 1 Presents Potent Anti-Inflammatory Activity JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26312490 #FOAvip The transforming growth factor beta 1 (TGF-?1) is a pleiotropic cytokine with multiple roles in development, wound healing, and immune regulation. TGF-?1-mediated immune dysfunction may lead to pathological conditions, such as inflammation. Chronic inflammatory process is characterized by a continuous release of pro-inflammatory cytokines, and the inhibition or the blockage of these cytokines signaling pathways are considered a target treatment. In this context, despite the high numbers of TGF-?-targeted pathways, the inducible regulatory T cells (iTreg) to control inflammation seems to be a promising approach. Our aim was to develop novel peptides through phage display (PhD) technology that could mimic TGF-?1 function with higher potency. Specific mimetic peptides were obtained through a PhD subtraction strategy from whole cell binding using TGF-?1 recombinant as a competitor during elution step. We have selected a peptide that seems to play an important role on cellular differentiation and modulation of TNF-? and IL-10 cytokines. The synthetic pm26TGF-?1 peptide tested in PBMC significantly down-modulated TNF-? and up-regulated IL-10 responses, leading to regulatory T cells (Treg) phenotype differentiation. Furthermore, the synthetic peptide was able to decrease leukocytes rolling in BALB/C mice and neutrophils migration during inflammatory process in C57BL/6 mice. These data suggest that this peptide may be useful for the treatment of inflammatory diseases, especially because it displays potent anti-inflammatory properties and do not exhibit neutrophils' chemoattraction. Twit Text FOAVip A Short Peptide That Mimics the Binding Domain of TGF- 1 Presents Potent Anti-Inflammatory Activity ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26312490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26312490 #FOAvip English Wikipedia <ref>{{Cite pmid|26312490 }}</ref> A Short Peptide That Mimics the Binding Domain of TGF-?1 Presents Potent Anti-Inflammatory Activity #MMPMID26312490 Vaz ER ; Fujimura PT ; Araujo GR ; da Silva CA ; Silva RL ; Cunha TM ; Lopes-Ferreira M ; Lima C ; Ferreira MJ ; Cunha-Junior JP ; Taketomi EA ; Goulart LR ; Ueira-Vieira C PLoS One 2015[]; 10 (8 ): e0136116 PMID26312490 show ga The transforming growth factor beta 1 (TGF-?1) is a pleiotropic cytokine with multiple roles in development, wound healing, and immune regulation. TGF-?1-mediated immune dysfunction may lead to pathological conditions, such as inflammation. Chronic inflammatory process is characterized by a continuous release of pro-inflammatory cytokines, and the inhibition or the blockage of these cytokines signaling pathways are considered a target treatment. In this context, despite the high numbers of TGF-?-targeted pathways, the inducible regulatory T cells (iTreg) to control inflammation seems to be a promising approach. Our aim was to develop novel peptides through phage display (PhD) technology that could mimic TGF-?1 function with higher potency. Specific mimetic peptides were obtained through a PhD subtraction strategy from whole cell binding using TGF-?1 recombinant as a competitor during elution step. We have selected a peptide that seems to play an important role on cellular differentiation and modulation of TNF-? and IL-10 cytokines. The synthetic pm26TGF-?1 peptide tested in PBMC significantly down-modulated TNF-? and up-regulated IL-10 responses, leading to regulatory T cells (Treg) phenotype differentiation. Furthermore, the synthetic peptide was able to decrease leukocytes rolling in BALB/C mice and neutrophils migration during inflammatory process in C57BL/6 mice. These data suggest that this peptide may be useful for the treatment of inflammatory diseases, especially because it displays potent anti-inflammatory properties and do not exhibit neutrophils' chemoattraction. |Animals [MESH] |Anti-Inflammatory Agents, Non-Steroidal/chemistry/*pharmacology [MESH] |Biomimetic Materials/chemistry/*pharmacology [MESH] |Female [MESH] |Humans [MESH] |Interleukin-10/immunology [MESH] |Leukocyte Rolling/*drug effects/immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Neutrophils/*immunology/pathology [MESH] |Peptides/chemistry/*pharmacology [MESH] |T-Lymphocytes, Regulatory/immunology/pathology [MESH] |Transforming Growth Factor beta1/chemistry/*pharmacology [MESH]A Short Peptide That Mimics the Binding Domain of TGF-?1 Presents Pote(epmc).pdf DeepDyve Pubget Overpricing