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10.1111/imm.12483 http://scihub22266oqcxt.onion/10.1111/imm.12483 C4552503!4552503 !25988395     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25988395 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunology 2015 ; 146 (1 ): 81-8 Nephropedia Template TP {{tp|p=25988395 |t=2015. Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3? regulatory T cells in skin-transplanted mice |pdf=|usr=}}{{25988395 }} gab.com Text Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3 regulatory T cells in skin-transplanted mice JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=25988395 #FOAvip Interleukin-33 (IL-33) has been a focus of study because of its variety of functions shaping CD4(+) T-cell biology. In the present work, we evaluated the modulatory effect of IL-33 on suppressor cells in an in vivo transplantation model. C57BL/6 wild-type mice were grafted with syngeneic or allogeneic skin transplants and treated with exogenous IL-33 daily. After 10 days of treatment, we analysed draining lymph node cellularity and found in allogeneic animals an increment in myeloid-derived suppressor cells, which co-express MHC-II, and become enriched upon IL-33 treatment. In line with this observation, inducible nitric oxide synthase and arginase 1 expression were also increased in allogeneic animals upon IL-33 administration. In addition, IL-33 treatment up-regulated the number of Foxp3(+) regulatory T (Treg) cells in the allogeneic group, complementing the healthier integrity of the allografts and the increased allograft survival. Moreover, we demonstrate that IL-33 promotes CD4(+) T-cell expansion and conversion of CD4(+)  Foxp3(-) T cells into CD4(+)  Foxp3(+) Treg cells in the periphery. Lastly, the cytokine pattern of ex vivo-stimulated draining lymph nodes indicates that IL-33 dampens interferon-? and IL-17 production, stimulating IL-10 secretion. Altogether, our work complements previous studies on the immune-modulatory activity of IL-33, showing that this cytokine affects myeloid-derived suppressor cells at the cell number and gene expression levels. More importantly, our research demonstrates for the first time that IL-33 allows for in vivo Foxp3(+) Treg cell conversion and favours an anti-inflammatory or tolerogenic state by skewing cytokine production. Therefore, our data suggest a potential use of IL-33 to prevent allograft rejection, bringing new therapeutics to the transplantation field. Twit Text FOAVip Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3 regulatory T cells in skin-transplanted mice ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=25988395 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25988395 #FOAvip English Wikipedia <ref>{{Cite pmid|25988395 }}</ref> Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3? regulatory T cells in skin-transplanted mice #MMPMID25988395 Gajardo T ; Morales RA ; Campos-Mora M ; Campos-Acuña J ; Pino-Lagos K Immunology 2015[Sep]; 146 (1 ): 81-8 PMID25988395 show ga Interleukin-33 (IL-33) has been a focus of study because of its variety of functions shaping CD4(+) T-cell biology. In the present work, we evaluated the modulatory effect of IL-33 on suppressor cells in an in vivo transplantation model. C57BL/6 wild-type mice were grafted with syngeneic or allogeneic skin transplants and treated with exogenous IL-33 daily. After 10 days of treatment, we analysed draining lymph node cellularity and found in allogeneic animals an increment in myeloid-derived suppressor cells, which co-express MHC-II, and become enriched upon IL-33 treatment. In line with this observation, inducible nitric oxide synthase and arginase 1 expression were also increased in allogeneic animals upon IL-33 administration. In addition, IL-33 treatment up-regulated the number of Foxp3(+) regulatory T (Treg) cells in the allogeneic group, complementing the healthier integrity of the allografts and the increased allograft survival. Moreover, we demonstrate that IL-33 promotes CD4(+) T-cell expansion and conversion of CD4(+)  Foxp3(-) T cells into CD4(+)  Foxp3(+) Treg cells in the periphery. Lastly, the cytokine pattern of ex vivo-stimulated draining lymph nodes indicates that IL-33 dampens interferon-? and IL-17 production, stimulating IL-10 secretion. Altogether, our work complements previous studies on the immune-modulatory activity of IL-33, showing that this cytokine affects myeloid-derived suppressor cells at the cell number and gene expression levels. More importantly, our research demonstrates for the first time that IL-33 allows for in vivo Foxp3(+) Treg cell conversion and favours an anti-inflammatory or tolerogenic state by skewing cytokine production. Therefore, our data suggest a potential use of IL-33 to prevent allograft rejection, bringing new therapeutics to the transplantation field. |*Skin Transplantation [MESH] |Animals [MESH] |Arginase/biosynthesis [MESH] |Cell Differentiation/immunology [MESH] |Cell Proliferation [MESH] |Forkhead Transcription Factors/immunology [MESH] |Graft Rejection/*immunology [MESH] |Graft Survival/*immunology [MESH] |Histocompatibility Antigens Class II/biosynthesis [MESH] |Immune Tolerance/drug effects/immunology [MESH] |Interferon-gamma/biosynthesis [MESH] |Interleukin-10/biosynthesis/metabolism [MESH] |Interleukin-17/biosynthesis [MESH] |Interleukin-33 [MESH] |Interleukins/*pharmacology [MESH] |Lymphocyte Activation/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myeloid Cells/immunology [MESH] |Nitric Oxide Synthase Type II/biosynthesis [MESH] |Skin/immunology [MESH] |T-Lymphocytes, Regulatory/cytology/*immunology [MESH] |Th1 Cells/cytology/immunology [MESH] |Th17 Cells/cytology/immunology [MESH]Exogenous interleukin-33 targets myeloid-derived suppressor cells and (epmc).pdf DeepDyve Pubget Overpricing