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10.1038/nn.4072 http://scihub22266oqcxt.onion/10.1038/nn.4072 C4552261!4552261!26237367     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2015 ; 18 (9): 1291-8 Nephropedia Template TP {{tp|p=26237367|t=2015. Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome |pdf=|usr=}}{{26237367}} gab.com Text Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26237367 #FOAvip Hippocampal pathology is likely to contribute to cognitive disability in Down syndrome (DS), yet the neural network basis of this pathology and its contributions to different facets of cognitive impairment remain unclear. Here, we report dysfunctional connectivity between dentate gyrus (DG) and CA3 networks in the transchromosomic Tc1 mouse model of DS, demonstrating that ultrastructural abnormalities and impaired short-term plasticity at DG-CA3 excitatory synapses culminate in impaired coding of novel spatial information in CA3 and CA1 and disrupted behaviour in vivo. These results highlight the vulnerability of DG-CA3 networks to aberrant human chromosome 21 gene expression, and delineate hippocampal circuit abnormalities likely to contribute to distinct cognitive phenotypes in DS. Twit Text FOAVip Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26237367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237367 #FOAvip English Wikipedia <ref>{{Cite pmid|26237367}}</ref> Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome #MMPMID26237367 Witton J; Padmashri R; Zinyuk L; Popov V; Kraev I; Line S; Jensen T; Tedoldi A; Cummings D; Tybulewicz V; Fisher E; Bannerman D; Randall A; Brown J; Edwards F; Rusakov D; Stewart M; Jones M Nat Neurosci 2015[Sep]; 18 (9): 1291-8 PMID26237367show ga Hippocampal pathology is likely to contribute to cognitive disability in Down syndrome (DS), yet the neural network basis of this pathology and its contributions to different facets of cognitive impairment remain unclear. Here, we report dysfunctional connectivity between dentate gyrus (DG) and CA3 networks in the transchromosomic Tc1 mouse model of DS, demonstrating that ultrastructural abnormalities and impaired short-term plasticity at DG-CA3 excitatory synapses culminate in impaired coding of novel spatial information in CA3 and CA1 and disrupted behaviour in vivo. These results highlight the vulnerability of DG-CA3 networks to aberrant human chromosome 21 gene expression, and delineate hippocampal circuit abnormalities likely to contribute to distinct cognitive phenotypes in DS. äHippocampal circuit dysfunction in the Tc1 mouse model of Down syndrom(epmc).pdf DeepDyve Pubget Overpricing