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10.1681/ASN.2014090940 http://scihub22266oqcxt.onion/10.1681/ASN.2014090940 C4552122!4552122!25636411     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2015 ; 26 (9): 2097-104 Nephropedia Template TP {{tp|p=25636411|t=2015. Genome-Wide Analysis of Wilms? Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms |pdf=|usr=}}{{25636411}} gab.com Text Genome-Wide Analysis of Wilms Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25636411 #FOAvip The transcription factor Wilms? tumor suppressor 1 (WT1) is key to podocyte development and viability; however, WT1 transcriptional networks in podocytes remain elusive. We provide a comprehensive analysis of the genome-wide WT1 transcriptional network in podocytes in vivo using chromatin immunoprecipitation followed by sequencing (ChIPseq) and RNA sequencing techniques. Our data show a specific role for WT1 in regulating the podocyte-specific transcriptome through binding to both promoters and enhancers of target genes. Furthermore, we inferred a podocyte transcription factor network consisting of WT1, LMX1B, TCF21, Fox-class and TEAD family transcription factors, and MAFB that uses tissue-specific enhancers to control podocyte gene expression. In addition to previously described WT1-dependent target genes, ChIPseq identified novel WT1-dependent signaling systems. These targets included components of the Hippo signaling system, underscoring the power of genome-wide transcriptional-network analyses. Together, our data elucidate a comprehensive gene regulatory network in podocytes suggesting that WT1 gene regulatory function and podocyte cell-type specification can best be understood in the context of transcription factor-regulatory element network interplay. Twit Text FOAVip Genome-Wide Analysis of Wilms Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25636411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25636411 #FOAvip English Wikipedia <ref>{{Cite pmid|25636411}}</ref> Genome-Wide Analysis of Wilms? Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms #MMPMID25636411 Kann M; Ettou S; Jung YL; Lenz MO; Taglienti ME; Park PJ; Schermer B; Benzing T; Kreidberg JA J Am Soc Nephrol 2015[Sep]; 26 (9): 2097-104 PMID25636411show ga The transcription factor Wilms? tumor suppressor 1 (WT1) is key to podocyte development and viability; however, WT1 transcriptional networks in podocytes remain elusive. We provide a comprehensive analysis of the genome-wide WT1 transcriptional network in podocytes in vivo using chromatin immunoprecipitation followed by sequencing (ChIPseq) and RNA sequencing techniques. Our data show a specific role for WT1 in regulating the podocyte-specific transcriptome through binding to both promoters and enhancers of target genes. Furthermore, we inferred a podocyte transcription factor network consisting of WT1, LMX1B, TCF21, Fox-class and TEAD family transcription factors, and MAFB that uses tissue-specific enhancers to control podocyte gene expression. In addition to previously described WT1-dependent target genes, ChIPseq identified novel WT1-dependent signaling systems. These targets included components of the Hippo signaling system, underscoring the power of genome-wide transcriptional-network analyses. Together, our data elucidate a comprehensive gene regulatory network in podocytes suggesting that WT1 gene regulatory function and podocyte cell-type specification can best be understood in the context of transcription factor-regulatory element network interplay. äGenome-Wide Analysis of Wilms? Tumor 1-Controlled Gene Expression in P(epmc).pdf DeepDyve Pubget Overpricing