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10.15252/emmm.201505245 http://scihub22266oqcxt.onion/10.15252/emmm.201505245 C4551339!4551339 !26089099     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26089099 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Mol+Med 2015 ; 7 (8 ): 996-1003 Nephropedia Template TP {{tp|p=26089099 |t=2015. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis |pdf=|usr=}}{{26089099 }} gab.com Text H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26089099 #FOAvip Endometriosis affects approximately 15% of reproductive aged women and is associated with chronic pelvic pain and infertility. However, the molecular mechanisms by which endometriosis impacts fertility are poorly understood. The developmentally regulated, imprinted H19 long noncoding RNA (lncRNA) functions to reduce the bioavailability of microRNA let-7 by acting as a molecular sponge. Here we report that H19 expression is significantly decreased in the eutopic endometrium of women with endometriosis as compared to normal controls. We show that decreased H19 increases let-7 activity, which in turn inhibits Igf1r expression at the post-transcriptional level, thereby contributing to reduced proliferation of endometrial stromal cells. We propose that perturbation of this newly identified H19/Let-7/IGF1R regulatory pathway may contribute to impaired endometrial preparation and receptivity for pregnancy in women with endometriosis. Our finding represents the first example of a lncRNA-based mechanism in endometriosis and its associated infertility, thus holding potential in the development of novel therapeutics for women with endometriosis and infertility. Twit Text FOAVip H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26089099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26089099 #FOAvip English Wikipedia <ref>{{Cite pmid|26089099 }}</ref> H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis #MMPMID26089099 Ghazal S ; McKinnon B ; Zhou J ; Mueller M ; Men Y ; Yang L ; Mueller M ; Flannery C ; Huang Y ; Taylor HS EMBO Mol Med 2015[Aug]; 7 (8 ): 996-1003 PMID26089099 show ga Endometriosis affects approximately 15% of reproductive aged women and is associated with chronic pelvic pain and infertility. However, the molecular mechanisms by which endometriosis impacts fertility are poorly understood. The developmentally regulated, imprinted H19 long noncoding RNA (lncRNA) functions to reduce the bioavailability of microRNA let-7 by acting as a molecular sponge. Here we report that H19 expression is significantly decreased in the eutopic endometrium of women with endometriosis as compared to normal controls. We show that decreased H19 increases let-7 activity, which in turn inhibits Igf1r expression at the post-transcriptional level, thereby contributing to reduced proliferation of endometrial stromal cells. We propose that perturbation of this newly identified H19/Let-7/IGF1R regulatory pathway may contribute to impaired endometrial preparation and receptivity for pregnancy in women with endometriosis. Our finding represents the first example of a lncRNA-based mechanism in endometriosis and its associated infertility, thus holding potential in the development of novel therapeutics for women with endometriosis and infertility. |*Cell Proliferation [MESH] |Endometriosis/*genetics/physiopathology [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |MicroRNAs/*metabolism [MESH] |RNA, Long Noncoding/genetics/*metabolism [MESH] |Receptor, IGF Type 1/*metabolism [MESH] |Signal Transduction [MESH] |Somatomedins/*metabolism [MESH]H19 lncRNA alters stromal cell growth via IGF signaling in the endomet(epmc).pdf DeepDyve Pubget Overpricing