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Effect of ?-aminobutyric acid on kidney injury induced by renal
ischemia-reperfusion in male and female rats: Gender-related difference
#MMPMID26380243
Vafapour M
; Nematbakhsh M
; Monajemi R
; Mazaheri S
; Talebi A
; Talebi N
; Shirdavani S
Adv Biomed Res
2015[]; 4
(?): 158
PMID26380243
show ga
BACKGROUND: The most important cause of kidney injury is renal
ischemia/reperfusion injury (IRI), which is gender-related. This study was
designed to investigate the protective role of ?-aminobutyric acid (GABA (against
IRI in male and female rats. MATERIALS AND METHODS: Thirty-six female and male
wistar rats were assigned to six experimental groups. The IRI was induced by
clamping renal vessels for 45 min then was performed reperfusion for 24 h. The
group sex posed to IRI were pretreated with GABA and were compared with the
control groups. RESULTS: Serum levels of creatinine and blood urea nitrogen,
kidney weight, and kidney tissue damage score increased in the IRI alone groups,
(P < 0.05), while GABA decreased these parameters in female significantly (P <
0.05), but not in male rats. Uterus weight decreased significantly in female rats
treated with GABA. Testis weight did not alter in male rats. Serum level of
nitrite and kidney level of malondialdehyde (MDA) had no significant change in
both female and male rats. Kidney level of nitrite increased significantly in
female rats experienced IRI and serum level of MDA increased significantly in
males that were exposed to IRI (P < 0.05). CONCLUSION: GABA could ameliorate
kidney injury induced by renal IRI in a gender dependent manner.
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