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10.1038/srep13474 http://scihub22266oqcxt.onion/10.1038/srep13474 C4550850!4550850 !26310847     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26310847 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 13474 Nephropedia Template TP {{tp|p=26310847 |t=2015. Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation |pdf=|usr=}}{{26310847 }} gab.com Text Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26310847 #FOAvip Herein, we report the characterization of Limb expression 1-like, (LIX1L), a putative RNA-binding protein (RBP) containing a double-stranded RNA binding motif, which is highly expressed in various cancer tissues. Analysis of MALDI-TOF/TOF mass spectrometry and RNA immunoprecipitation-sequencing of interacting proteins and the microRNAs (miRNAs) bound to LIX1L revealed that LIX1L interacts with proteins (RIOK1, nucleolin and PABPC4) and miRNAs (has-miRNA-520a-5p, -300, -216b, -326, -190a, -548b-3p, -7-5p and -1296) in HEK-293 cells. Moreover, the reduction of phosphorylated Tyr(136) (pTyr(136)) in LIX1L through the homeodomain peptide, PY136, inhibited LIX1L-induced cell proliferation in vitro, and PY136 inhibited MKN45 cell proliferation in vivo. We also determined the miRNA-targeted genes and showed that was apoptosis induced through the reduction of pTyr(136). Moreover, ROS1, HCK, ABL1, ABL2, JAK3, LCK and TYR03 were identified as candidate kinases responsible for the phosphorylation of Tyr(136) of LIX1L. These data provide novel insights into the biological significance of LIX1L, suggesting that this protein might be an RBP, with implications for therapeutic approaches for targeting LIX1L in LIX1L-expressing cancer cells. Twit Text FOAVip Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26310847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26310847 #FOAvip English Wikipedia <ref>{{Cite pmid|26310847 }}</ref> Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation #MMPMID26310847 Nakamura S ; Kahyo T ; Tao H ; Shibata K ; Kurabe N ; Yamada H ; Shinmura K ; Ohnishi K ; Sugimura H Sci Rep 2015[Aug]; 5 (ä): 13474 PMID26310847 show ga Herein, we report the characterization of Limb expression 1-like, (LIX1L), a putative RNA-binding protein (RBP) containing a double-stranded RNA binding motif, which is highly expressed in various cancer tissues. Analysis of MALDI-TOF/TOF mass spectrometry and RNA immunoprecipitation-sequencing of interacting proteins and the microRNAs (miRNAs) bound to LIX1L revealed that LIX1L interacts with proteins (RIOK1, nucleolin and PABPC4) and miRNAs (has-miRNA-520a-5p, -300, -216b, -326, -190a, -548b-3p, -7-5p and -1296) in HEK-293 cells. Moreover, the reduction of phosphorylated Tyr(136) (pTyr(136)) in LIX1L through the homeodomain peptide, PY136, inhibited LIX1L-induced cell proliferation in vitro, and PY136 inhibited MKN45 cell proliferation in vivo. We also determined the miRNA-targeted genes and showed that was apoptosis induced through the reduction of pTyr(136). Moreover, ROS1, HCK, ABL1, ABL2, JAK3, LCK and TYR03 were identified as candidate kinases responsible for the phosphorylation of Tyr(136) of LIX1L. These data provide novel insights into the biological significance of LIX1L, suggesting that this protein might be an RBP, with implications for therapeutic approaches for targeting LIX1L in LIX1L-expressing cancer cells. |Actin Depolymerizing Factors/metabolism [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Apoptosis/drug effects/genetics [MESH] |Blotting, Western [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Electrophoresis, Gel, Two-Dimensional [MESH] |Enzyme Assays [MESH] |Gene Knockdown Techniques [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Immunohistochemistry [MESH] |Mass Spectrometry [MESH] |Mice, Nude [MESH] |MicroRNAs/genetics/metabolism [MESH] |Molecular Sequence Data [MESH] |Peptides/chemistry/pharmacology [MESH] |Phosphorylation/drug effects [MESH] |Protein-Tyrosine Kinases/*metabolism [MESH] |Proteomics [MESH] |Proto-Oncogene Proteins/*metabolism [MESH] |RNA-Binding Proteins/*metabolism [MESH] |Software [MESH] |Stomach Neoplasms/*metabolism/*pathology [MESH]Novel roles for LIX1L in promoting cancer cell proliferation through (epmc).pdf DeepDyve Pubget Overpricing