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10.1016/j.jvs.2014.11.086 http://scihub22266oqcxt.onion/10.1016/j.jvs.2014.11.086 C4550501!4550501!26206580     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26206580.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Vasc+Surg 2015 ; 62 (3): 585-93 Nephropedia Template TP {{tp|p=26206580|t=2015. Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm |pdf=|usr=}}{{26206580}} gab.com Text Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm JO: J Vasc Surg http://www.kidney.de/pget.php?&tw=1&pmid=26206580 #FOAvip Objective: Little is known regarding the etiological factors which lead to the occurrence of intraluminal thrombus (ILT) during abdominal aortic aneurysm (AAA) development. Recent work has suggested that macrophages may play an important role in progression of a number of other vascular diseases, including atherosclerosis; however, it is unknown whether these cells are present within the ILT of a progressing AAA. The purpose of this work was to define the presence, phenotype and spatial distribution of macrophages within ILT excised from six human patients. We hypothesized that the ILT contains a population of activated macrophages with a distinct, non-classical phenotypic profile. Methods: ILT samples were examined using histologic staining and immunofluorescent labeling for multiple markers of activated macrophages (CD45, CD68, HLA-DR, MMP9), as well as additional markers ?-SMA, CD34, CD105, FLK-1, and collagen I and III. Results: Histologic staining revealed a distinct laminar organization of collagen within the shoulder region of the ILT lumen and a spatially heterogeneous cell composition within the ILT. The majority of the cellular constituents of the ILT were in the luminal region and predominantly expressed markers of activated macrophages but also concurrently expressed ?-SMA, CD105 and synthesized collagen I and III Conclusions: Our results demonstrate that the luminal layer of human ILT is rich in a distinct population of activated macrophages. Additional work is needed to assess the contribution of these cells to ILT formation and the pathobiology of AAA as a whole. Summary: The present manuscript presents evidence for the presence of a distinct macrophage population within the luminal region of AAA ILT. These cells express a set of markers indicative of a unique population of activated macrophages. The exact contributions of these previously unrecognized cells to ILT formation and AAA pathobiology remains unknown. Twit Text FOAVip Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm ????J Vasc Surg http://www.kidney.de/pget.php?&tw=1&pmid=26206580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26206580 #FOAvip English Wikipedia <ref>{{Cite pmid|26206580}}</ref> Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm #MMPMID26206580 Rao J; Brown BN; Weinbaum JS; Ofstun E; Makaroun MS; Humphrey JD; Vorp DA J Vasc Surg 2015[Sep]; 62 (3): 585-93 PMID26206580show ga Objective: Little is known regarding the etiological factors which lead to the occurrence of intraluminal thrombus (ILT) during abdominal aortic aneurysm (AAA) development. Recent work has suggested that macrophages may play an important role in progression of a number of other vascular diseases, including atherosclerosis; however, it is unknown whether these cells are present within the ILT of a progressing AAA. The purpose of this work was to define the presence, phenotype and spatial distribution of macrophages within ILT excised from six human patients. We hypothesized that the ILT contains a population of activated macrophages with a distinct, non-classical phenotypic profile. Methods: ILT samples were examined using histologic staining and immunofluorescent labeling for multiple markers of activated macrophages (CD45, CD68, HLA-DR, MMP9), as well as additional markers ?-SMA, CD34, CD105, FLK-1, and collagen I and III. Results: Histologic staining revealed a distinct laminar organization of collagen within the shoulder region of the ILT lumen and a spatially heterogeneous cell composition within the ILT. The majority of the cellular constituents of the ILT were in the luminal region and predominantly expressed markers of activated macrophages but also concurrently expressed ?-SMA, CD105 and synthesized collagen I and III Conclusions: Our results demonstrate that the luminal layer of human ILT is rich in a distinct population of activated macrophages. Additional work is needed to assess the contribution of these cells to ILT formation and the pathobiology of AAA as a whole. Summary: The present manuscript presents evidence for the presence of a distinct macrophage population within the luminal region of AAA ILT. These cells express a set of markers indicative of a unique population of activated macrophages. The exact contributions of these previously unrecognized cells to ILT formation and AAA pathobiology remains unknown. äDistinct macrophage phenotype and collagen organization within the int(epmc).pdf DeepDyve Pubget Overpricing