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10.1371/journal.pcbi.1004474 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1004474 C4550276!4550276!26308508     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Comput+Biol 2015 ; 11 (8): ä Nephropedia Template TP {{tp|p=26308508|t=2015. Mechanism for Collective Cell Alignment in Myxococcus xanthus Bacteria |pdf=|usr=}}{{26308508}} gab.com Text Mechanism for Collective Cell Alignment in Myxococcus xanthus Bacteria JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=26308508 #FOAvip Myxococcus xanthus cells self-organize into aligned groups, clusters, at various stages of their lifecycle. Formation of these clusters is crucial for the complex dynamic multi-cellular behavior of these bacteria. However, the mechanism underlying the cell alignment and clustering is not fully understood. Motivated by studies of clustering in self-propelled rods, we hypothesized that M. xanthus cells can align and form clusters through pure mechanical interactions among cells and between cells and substrate. We test this hypothesis using an agent-based simulation framework in which each agent is based on the biophysical model of an individual M. xanthus cell. We show that model agents, under realistic cell flexibility values, can align and form cell clusters but only when periodic reversals of cell directions are suppressed. However, by extending our model to introduce the observed ability of cells to deposit and follow slime trails, we show that effective trail-following leads to clusters in reversing cells. Furthermore, we conclude that mechanical cell alignment combined with slime-trail-following is sufficient to explain the distinct clustering behaviors observed for wild-type and non-reversing M. xanthus mutants in recent experiments. Our results are robust to variation in model parameters, match the experimentally observed trends and can be applied to understand surface motility patterns of other bacterial species. Twit Text FOAVip Mechanism for Collective Cell Alignment in Myxococcus xanthus Bacteria ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=26308508 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26308508 #FOAvip English Wikipedia <ref>{{Cite pmid|26308508}}</ref> Mechanism for Collective Cell Alignment in Myxococcus xanthus Bacteria #MMPMID26308508 Balagam R; Igoshin OA PLoS Comput Biol 2015[Aug]; 11 (8): ä PMID26308508show ga Myxococcus xanthus cells self-organize into aligned groups, clusters, at various stages of their lifecycle. Formation of these clusters is crucial for the complex dynamic multi-cellular behavior of these bacteria. However, the mechanism underlying the cell alignment and clustering is not fully understood. Motivated by studies of clustering in self-propelled rods, we hypothesized that M. xanthus cells can align and form clusters through pure mechanical interactions among cells and between cells and substrate. We test this hypothesis using an agent-based simulation framework in which each agent is based on the biophysical model of an individual M. xanthus cell. We show that model agents, under realistic cell flexibility values, can align and form cell clusters but only when periodic reversals of cell directions are suppressed. However, by extending our model to introduce the observed ability of cells to deposit and follow slime trails, we show that effective trail-following leads to clusters in reversing cells. Furthermore, we conclude that mechanical cell alignment combined with slime-trail-following is sufficient to explain the distinct clustering behaviors observed for wild-type and non-reversing M. xanthus mutants in recent experiments. Our results are robust to variation in model parameters, match the experimentally observed trends and can be applied to understand surface motility patterns of other bacterial species. äMechanism for Collective Cell Alignment in Myxococcus xanthus Bacteria(epmc).pdf DeepDyve Pubget Overpricing