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10.1177/2040622315589934

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suck abstract from ncbi


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pmid26336594
      Ther+Adv+Chronic+Dis 2015 ; 6 (5 ): 252-63
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  • Managing hyperphosphatemia in patients with chronic kidney disease on dialysis with ferric citrate: latest evidence and clinical usefulness #MMPMID26336594
  • Yagil Y ; Fadem SZ ; Kant KS ; Bhatt U ; Sika M ; Lewis JB ; Negoi D
  • Ther Adv Chronic Dis 2015[Sep]; 6 (5 ): 252-63 PMID26336594 show ga
  • Ferric citrate is a novel phosphate binder that allows the simultaneous treatment of hyperphosphatemia and iron deficiency in patients being treated for end-stage renal disease with hemodialysis (HD). Multiple clinical trials in HD patients have uniformly and consistently demonstrated the efficacy of the drug in controlling hyperphosphatemia with a good safety profile, leading the US Food and Drug Administration in 2014 to approve its use for that indication. A concurrent beneficial effect, while using ferric citrate as a phosphate binder, is its salutary effect in HD patients with iron deficiency being treated with an erythropoietin-stimulating agent (ESA) in restoring iron that becomes available for reversing chronic kidney disease (CKD)-related anemia. Ferric citrate has also been shown in several studies to diminish the need for intravenous iron treatment and to reduce the requirement for ESA. Ferric citrate is thus a preferred phosphate binder that helps resolve CKD-related mineral bone disease and iron-deficiency anemia.
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