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10.1111/cea.12573

http://scihub22266oqcxt.onion/10.1111/cea.12573
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C4549207!4549207!26011047
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suck abstract from ncbi


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pmid26011047      Clin+Exp+Allergy 2015 ; 45 (9): 1439-46
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  • Cough During Infancy and Subsequent Childhood Asthma #MMPMID26011047
  • Oren E; Rothers J; Stern DA; Morgan WJ; Halonen M; Wright AL
  • Clin Exp Allergy 2015[Sep]; 45 (9): 1439-46 PMID26011047show ga
  • OBJECTIVES: Wheezing in infancy has been associated with subsequent asthma, but whether cough similarly influences asthma risk has been little studied. We sought to determine whether prolonged cough and cough without cold in the first year of life are associated with childhood asthma. METHODS: Participants in the Infant Immune Study, a non-selected birth cohort, were surveyed 7 times in the first 9 months of life regarding presence of wheeze and cough. Cough for more than 28 days was defined as prolonged. Parents were asked at 1 year if the child ever coughed without a cold. Asthma was defined as parental report of physician diagnosis of asthma, with symptoms or medication use between 2?9 years. Logistic regression was used to assess adjusted odds for asthma associated with cough characteristics. RESULTS: 24% (97) of children experienced prolonged cough and 23% (95) cough without cold in the first 9 months, respectively. Prolonged cough was associated with increased risk of asthma relative to brief cough (OR 3.57, CI: 1.88, 6.76), with the risk being particularly high among children of asthmatic mothers. Cough without cold (OR 3.13, 95% CI: 1.76, 5.57) was also independently associated with risk of childhood asthma. Both relations persisted after adjustment for wheeze and total IgE at age 1. CONCLUSIONS AND CLINICAL RELEVANCE: Prolonged cough in infancy and cough without cold are associated with childhood asthma, independent of infant wheeze. These findings suggest that characteristics of cough in infancy are early markers of asthma susceptibility, particularly among children with maternal asthma.
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