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10.1186/s13059-015-0740-z

http://scihub22266oqcxt.onion/10.1186/s13059-015-0740-z
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C4549084!4549084!26272203
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suck abstract from ncbi

pmid26272203      Genome+Biol 2015 ; 16 (1): ä
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  • Predicting chromatin organization using histone marks #MMPMID26272203
  • Huang J; Marco E; Pinello L; Yuan GC
  • Genome Biol 2015[]; 16 (1): ä PMID26272203show ga
  • Genome-wide mapping of three dimensional chromatin organization is an important yet technically challenging task. To aid experimental effort and to understand the determinants of long-range chromatin interactions, we have developed a computational model integrating Hi-C and histone mark ChIP-seq data to predict two important features of chromatin organization: chromatin interaction hubs and topologically associated domain (TAD) boundaries. Our model accurately and robustly predicts these features across datasets and cell types. Cell-type specific histone mark information is required for prediction of chromatin interaction hubs but not for TAD boundaries. Our predictions provide a useful guide for the exploration of chromatin organization.Electronic supplementary material: The online version of this article (doi:10.1186/s13059-015-0740-z) contains supplementary material, which is available to authorized users.
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