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2015 ; 2
(3
): 330-5
Nephropedia Template TP
gab.com Text
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English Wikipedia
Sickle Cell Trait from a Metabolic, Renal, and Vascular Perspective: Linking
History, Knowledge, and Health
#MMPMID26322267
Thoreson CK
; O'Connor MY
; Ricks M
; Chung ST
; Sumner AE
J Racial Ethn Health Disparities
2015[Sep]; 2
(3
): 330-5
PMID26322267
show ga
Sickle cell trait (SCT) is at the intersection of genetics, social policy, and
medicine. SCT occurs in three-hundred million people worldwide and in
approximately 8 % of African-Americans. There has been great debate about the
influence of SCT on health. Yet data exist, albeit controversial, which suggest
that SCT is associated with metabolic derangements that can lead to sudden death
after vigorous physical activity, renal dysfunction, thromboembolic events, and
stroke. In addition, it has even been postulated that SCT might enhance the
vascular complications of diabetes. This review focuses on (a) the scientific
breakthroughs that led to the discovery of hemoglobin S, sickle cell disease, and
SCT, (b) the history of screening programs in the United States, (c) the
incidence and etiology of exercise-related sudden death in military personnel and
athletes with SCT, and (d) the data examining the potential chronic disease
consequences of SCT from a metabolic, renal, and vascular perspective.
|*Sickle Cell Trait/ethnology
[MESH]
|Athletes/statistics & numerical data
[MESH]
|Biomedical Research
[MESH]
|Chronic Disease
[MESH]
|Death, Sudden/epidemiology/etiology
[MESH]
|Exercise
[MESH]
|History, 20th Century
[MESH]
|Humans
[MESH]
|Mass Screening/history
[MESH]
|Military Personnel/statistics & numerical data
[MESH]