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10.1371/journal.pbio.1002236

http://scihub22266oqcxt.onion/10.1371/journal.pbio.1002236
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suck abstract from ncbi


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      PLoS+Biol 2015 ; 13 (8 ): e1002236
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  • The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence #MMPMID26305571
  • Boots M
  • PLoS Biol 2015[Aug]; 13 (8 ): e1002236 PMID26305571 show ga
  • There is little doubt evolution has played a major role in preventing the control of infectious disease through antibiotic and insecticide resistance, but recent theory suggests disease interventions such as vaccination may lead to evolution of more harmful parasites. A new study published in PLOS Biology by Andrew Read and colleagues shows empirically that vaccination against Marek's disease has favored higher virulence; without intervention, the birds die too quickly for any transmission to occur, but vaccinated hosts can both stay alive longer and shed the virus. This is an elegant empirical demonstration of how evolutionary theory can predict potentially dangerous responses of infectious disease to human interventions.
  • |*Selection, Genetic [MESH]
  • |Animals [MESH]
  • |Mardivirus/*pathogenicity [MESH]
  • |Marek Disease Vaccines/*adverse effects [MESH]


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