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2015 ; 13
(8
): e1002236
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The Need for Evolutionarily Rational Disease Interventions: Vaccination Can
Select for Higher Virulence
#MMPMID26305571
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PLoS Biol
2015[Aug]; 13
(8
): e1002236
PMID26305571
show ga
There is little doubt evolution has played a major role in preventing the control
of infectious disease through antibiotic and insecticide resistance, but recent
theory suggests disease interventions such as vaccination may lead to evolution
of more harmful parasites. A new study published in PLOS Biology by Andrew Read
and colleagues shows empirically that vaccination against Marek's disease has
favored higher virulence; without intervention, the birds die too quickly for any
transmission to occur, but vaccinated hosts can both stay alive longer and shed
the virus. This is an elegant empirical demonstration of how evolutionary theory
can predict potentially dangerous responses of infectious disease to human
interventions.