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10.1016/j.it.2015.07.006 http://scihub22266oqcxt.onion/10.1016/j.it.2015.07.006 C4548828!4548828!26298065     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2015 ; 36 (9): 507-18 Nephropedia Template TP {{tp|p=26298065|t=2015. Exploiting genomics and natural genetic variation to decode macrophage enhancers |pdf=|usr=}}{{26298065}} gab.com Text Exploiting genomics and natural genetic variation to decode macrophage enhancers JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26298065 #FOAvip The mammalian genome contains on the order of a million enhancer-like regions that are required to establish the identities and functions of specific cell types. Here, we review recent studies in immune cells that have provided insight into the mechanisms that selectively activate certain enhancers in response to cell lineage and environmental signals. We describe a working model wherein distinct classes of transcription factors define the repertoire of active enhancers in macrophages through collaborative and hierarchical interactions, and discuss important challenges to this model, specifically providing examples from T cells. We conclude by discussing the use of natural genetic variation as a powerful approach for decoding transcription factor combinations that play dominant roles in establishing the enhancer landscapes, and the potential that these insights have for advancing our understanding of the molecular causes of human disease. Twit Text FOAVip Exploiting genomics and natural genetic variation to decode macrophage enhancers ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26298065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26298065 #FOAvip English Wikipedia <ref>{{Cite pmid|26298065}}</ref> Exploiting genomics and natural genetic variation to decode macrophage enhancers #MMPMID26298065 Romanoski CE; Link VM; Heinz S; Glass CK Trends Immunol 2015[Sep]; 36 (9): 507-18 PMID26298065show ga The mammalian genome contains on the order of a million enhancer-like regions that are required to establish the identities and functions of specific cell types. Here, we review recent studies in immune cells that have provided insight into the mechanisms that selectively activate certain enhancers in response to cell lineage and environmental signals. We describe a working model wherein distinct classes of transcription factors define the repertoire of active enhancers in macrophages through collaborative and hierarchical interactions, and discuss important challenges to this model, specifically providing examples from T cells. We conclude by discussing the use of natural genetic variation as a powerful approach for decoding transcription factor combinations that play dominant roles in establishing the enhancer landscapes, and the potential that these insights have for advancing our understanding of the molecular causes of human disease. äExploiting genomics and natural genetic variation to decode macrophage(epmc).pdf DeepDyve Pubget Overpricing