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2015 ; 72
(3
): 165-70
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Risk of cancer in workers exposed to styrene at eight British companies making
glass-reinforced plastics
#MMPMID25358742
Coggon D
; Ntani G
; Harris EC
; Palmer KT
Occup Environ Med
2015[Mar]; 72
(3
): 165-70
PMID25358742
show ga
OBJECTIVES: To provide further information on the risks of lymphohaematopoietic
(LH) and other cancers associated with styrene. METHODS: We extended follow-up to
December 2012 for 7970 workers at eight companies in England which used styrene
in the manufacture of glass-reinforced plastics. Mortality was compared with that
for England and Wales by the person-years method, and summarised by SMRs with 95%
CIs. A supplementary nested case-control analysis compared styrene exposures,
lagged by 5?years, in 122 incident or fatal cases of LH cancer and 1138 matched
controls. RESULTS: A total of 3121 cohort members had died (2022 since the last
follow-up). No elevation of mortality was observed for LH cancer, either in the
full cohort (62 deaths, SMR 0.90, 95% CI 0.69 to 1.15), or in those with more
than background exposure to styrene (38 deaths, SMR 0.82, 95% CI 0.58 to 1.14).
Nor did the case-control analysis suggest any association with LH cancer. In
comparison with background exposure, the OR for non-Hodgkin's lymphoma/chronic
lymphocytic leukaemia in workers with high exposure (estimated 8-h time-weighted
average of 40-100?ppm) for ?1?year was 0.54 (95% CI 0.23 to 1.27). Mortality from
lung cancer was significantly elevated, and risk increased progressively across
exposure categories, with an SMR of 1.44 (95% CI 1.10 to 1.86) in workers highly
exposed for ?1?year. CONCLUSIONS: We found no evidence that styrene causes LH
cancer. An association with lung cancer is not consistently supported by other
studies. It may have been confounded by smoking, but would be worth checking
further.
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